Evidence map›Paper›PMID 25266122›Full record

ArticleMolecular psychiatry2015

Addiction-related genes in gambling disorders: new insights from parallel human and pre-clinical models.

D S S Lobo, L Aleksandrova, J Knight, D M Casey, N el-Guebaly, J N Nobrega, J L Kennedy

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
  2. Article
  3. Biochemical Diagnosis in Substance and Non-substance Addiction.Advances in experimental medicine and biology · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Neural and neurocognitive markers of vulnerability to gambling disorder: a study of unaffected siblings.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Gambling disorder: an integrative review of animal and human studies.Annals of the New York Academy of Sciences · 2017
    Review
  15. Article
  16. Article
  17. Dopamine D3 Receptor Availability Is Associated with Inflexible Decision Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Article
  18. Dopamine D3 Receptors Modulate the Ability of Win-Paired Cues to Increase Risky Choice in a Rat Gambling Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

D S S Lobo1] Department of Psychiatry, University of Toronto, Centre for Addiction and Mental Health, Toronto, ON, Canada [2] Centre for Addiction and Mental Health, Toronto, ON, Canada.
L Aleksandrova1] Centre for Addiction and Mental Health, Toronto, ON, Canada [2] Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
J Knight1] Department of Psychiatry, University of Toronto, Centre for Addiction and Mental Health, Toronto, ON, Canada [2] Centre for Addiction and Mental Health, Toronto, ON, Canada.
D M CaseyMental Health Commission of Canada, Calgary, AB, Canada.
N el-GuebalyDivision of Addiction, Department of Psychiatry, University of Calgary, Calgary, AB, Canada.
J N Nobrega1] Centre for Addiction and Mental Health, Toronto, ON, Canada [2] Departments of Pharmacology and Toxicology, Psychiatry, and Psychology, University of Toronto, Toronto, ON, Canada.
J L Kennedy1] Department of Psychiatry, University of Toronto, Centre for Addiction and Mental Health, Toronto, ON, Canada [2] Centre for Addiction and Mental Health, Toronto, ON, Canada.
Centre for Addiction and Mental Health · CAMental Health Commission of Canada · CAUniversity of Calgary · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurobiological research supports the characterization of disordered gambling (DG) as a behavioral addiction. Recently, an animal model of gambling behavior was developed (rat gambling task, rGT), expanding the available tools to investigate DG neurobiology. We investigated whether rGT performance and associated risk gene expression in the rat's brain could provide cross-translational understanding of the neuromolecular mechanisms of addiction in DG. We genotyped tagSNPs (single-nucleotide polymorphisms) in 38 addiction-related genes in 400 DG and 345 non-DG subjects. Genes with P<0.1 in the human association analyses were selected to be investigated in the animal arm to determine whether their mRNA expression in rats was associated with the rat's performance on the rGT. In humans, DG was significantly associated with tagSNPs in DRD3 (rs167771) and CAMK2D (rs3815072). Our results suggest that age and gender might moderate the association between CAMK2D and DG. Moderation effects could not be investigated due to sample power. In the animal arm, only the association between rGT performance and Drd3 expression remained significant after Bonferroni correction for 59 brain regions. As male rats were used, gender effects could not be investigated. Our results corroborate previous findings reporting the involvement of DRD3 receptor in addictions. To our knowledge, the use of human genetics, pre-clinical models and gene expression as a cross-translation paradigm has not previously been attempted in the field of addictions. The cross-validation of human findings in animal models is crucial for improving the translation of basic research into clinical treatments, which could accelerate neurobiological and pharmacological investigations in addictions.

Indexed as

AdultAnimalsBehavior, AddictiveBrainCalcium-Calmodulin-Dependent Protein Kinase Type 2Disease Models, AnimalFemaleGamblingGames, ExperimentalGenetic Association StudiesGenetic Predisposition to DiseaseHumansMalePolymorphism, Single NucleotideRats, Sprague-DawleyReceptors, Dopamine D3Calcium-Calmodulin-Dependent Protein Kinase Type 2CAMK2D protein, humanDRD3 protein, humanDrd3 protein, ratReceptors, Dopamine D3RNA, Messenger

Identifiers

PMID25266122
OpenAlexW2081435628

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.