ArticleJournal of cancer research and clinical oncology2015
Downregulation of 425G>a variant of calcium-binding protein S100A14 associated with poor differentiation and prognosis in gastric cancer.
Article in Journal of cancer research and clinical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Prognostic and clinicopathological significance of S100A14 expression in cancer patients: A meta-analysis.Medicine · 2019Pooled it
- Computational Tactics for Precision Cancer Network Biology.International journal of molecular sciences · 2022Review
- Persistent Properties of a Subpopulation of Cancer Cells Overexpressing the Hedgehog Receptor Patched.Pharmaceutics · 2022Article
- S100 family members: potential therapeutic target in patients with hepatocellular carcinoma: A STROBE study.Medicine · 2021Observational
- Expression profile and functional role of S100A14 in human cancer.Oncotarget · 2019Review
- The prognostic value of S100A10 expression in cancer.Oncology letters · 2019Review
- Thymic Microenvironment Is Modified by Malnutrition andFrontiers in cellular and infection microbiology · 2019Article
- Activated Wnt signaling promotes growth and progression of AFP-producing gastric cancer in preclinical models.Cancer management and research · 2019Article
- S100A10 and Cancer Hallmarks: Structure, Functions, and its Emerging Role in Ovarian Cancer.International journal of molecular sciences · 2018Review
- Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence.Nature medicine · 2017Article
- Article
- Calcium-binding protein S100A14 induces differentiation and suppresses metastasis in gastric cancer.Cell death & disease · 2017Article
- What gastric cancer proteomic studies show about gastric carcinogenesis?Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Expression and clinical implication of S100A12 in gastric carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Role of S100 Proteins in Colorectal Carcinogenesis.Gastroenterology research and practice · 2016Review
- Co-expression of S100A14 and S100A16 correlates with a poor prognosis in human breast cancer and promotes cancer cell invasion.BMC cancer · 2015Article
- A Clinicopathological Analysis of S100A14 Expression in Colorectal Cancer.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAltered level of S100 calcium-binding proteins is involved in tumor development and progression. However, their role in gastric cancer (GC) is not well documented. We investigated the expression pattern of S100 proteins and differentiation or prognosis as well as possible mechanisms in GC.
methodsRT-PCR, Western blot analysis, and immunohistochemistry were used to determine the mRNA and protein expression of S100 family genes in GC. The polymorphisms of promoter and 5'-UTR of S100A14 gene were identified and related to luciferase reporter gene activity. Association of S100A14 expression with clinicopathologic features and survival in GC was analyzed.
resultsWe detected upregulated S100A2, S100A6, S100A10, and S100A11 expression and downregulated S100P and S100B expression in GC. Particularly, we detected differential mRNA and protein expression of S100A14 in GC cell lines and primary tumors. Furthermore, S100A14 expression change was related to a differentiated GC phenotype, with an expression in 31/40 (77.5 %) samples of well-differentiated tumors and 29/85 (34.1 %) samples of poorly differentiated tumors (P < 0.001). Moreover, 5-year survival was better in GC cases with positive than negative S100A14 level (P = 0.02). The genetic variant 425G>A on the 5'-UTR of S100A14 was associated with reduced S100A14 expression in GC cells.
conclusionDecreased expression of S100A14 with presence of its genetic variant 425G>A may be associated with an undifferentiated phenotype and poor prognosis in GC.
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