ArticleJournal of cellular and molecular medicine2014
Fabp4-CreER lineage tracing reveals two distinctive coronary vascular populations.
Article in Journal of cellular and molecular medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Coronary endothelial cells receive Notch1 signal during heart development.Biochemistry and biophysics reports · 2026Article
- Mechanosensitive PIEZO2 channels shape coronary artery development.Nature cardiovascular research · 2025Article
- Studying the Pulmonary Endothelium in Health and Disease: An Official American Thoracic Society Workshop Report.American journal of respiratory cell and molecular biology · 2024Article
- Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac Hypertrophy.Circulation research · 2024Article
- Sox7-positive endothelial progenitors establish coronary arteries and govern ventricular compaction.EMBO reports · 2023Article
- Modeling Human Heart Development and Congenital Defects Using Organoids: How Close Are We?Journal of cardiovascular development and disease · 2022Review
- Article
- Endothelial-Myocardial Angiocrine Signaling in Heart Development.Frontiers in cell and developmental biology · 2021Review
- Coronary vessel formation in development and disease: mechanisms and insights for therapy.Nature reviews. Cardiology · 2020Review
- The Formation of Coronary Vessels in Cardiac Development and Disease.Cold Spring Harbor perspectives in biology · 2020Review
- Pharmacological and genetic inhibition of fatty acid-binding protein 4 alleviated cisplatin-induced acute kidney injury.Journal of cellular and molecular medicine · 2019Article
- Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart.Nature communications · 2019Article
- Endothelial-Specific Cre Mouse Models.Arteriosclerosis, thrombosis, and vascular biology · 2018Review
- The Development and Regeneration of Coronary Arteries.Current cardiology reports · 2018Review
- Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development.Developmental cell · 2018Article
- Myocardial Bmp2 gain causes ectopic EMT and promotes cardiomyocyte proliferation and immaturity.Cell death & disease · 2018Article
- Myocardial Notch1-Rbpj deletion does not affect NOTCH signaling, heart development or function.PloS one · 2018Article
- Preexisting endothelial cells mediate cardiac neovascularization after injury.The Journal of clinical investigation · 2017Article
- Identification of a hybrid myocardial zone in the mammalian heart after birth.Nature communications · 2017Article
- More than Just a Simple Cardiac Envelope; Cellular Contributions of the Epicardium.Frontiers in cell and developmental biology · 2017Review
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Authors and funding
5 authors.
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Abstract
Over the last two decades, genetic lineage tracing has allowed for the elucidation of the cellular origins and fates during both embryogenesis and in pathological settings in adults. Recent lineage tracing studies using Apln-CreER tool indicated that a large number of post-natal coronary vessels do not form from pre-existing vessels. Instead, they form de novo after birth, which represents a coronary vascular population (CVP) distinct from the pre-existing one. Herein, we present new coronary vasculature lineage tracing results using a novel tool, Fabp4-CreER. Our results confirm the distinct existence of two unique CVPs. The 1(st) CVP, which is labelled by Fabp4-CreER, arises through angiogenic sprouting of pre-existing vessels established during early embryogenesis. The 2(nd) CVP is not labelled by Fabp4, suggesting that these vessels form de novo, rather than through expansion of the 1(st) CVP. These results support the de novo formation of vessels in the post-natal heart, which has implications for studies in cardiovascular disease and heart regeneration.
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