ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2014
Acoustic characterization of contrast-to-tissue ratio and axial resolution for dual-frequency contrast-specific acoustic angiography imaging.
Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 62 citations in OpenAlex.
- Intravascular ultrasound wall shear stress imaging in stented coronary arteries with ultrafast Doppler.Scientific reports · 2026Article
- Echocardiographic Assessment of Cardiac Function in Mouse Models of Heart Disease.International journal of molecular sciences · 2025Review
- Article
- A Handheld Imaging Probe for Acoustic Angiography With an Ultrawideband Capacitive Micromachined Ultrasonic Transducer (CMUT) Array.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Evaluation of Nonlinear Contrast Pulse Sequencing for Use in Super-Resolution Ultrasound Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Characterization of an Array-Based Dual-Frequency Transducer for Superharmonic Contrast Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Imaging methods to evaluate tumor microenvironment factors affecting nanoparticle drug delivery and antitumor response.Cancer drug resistance (Alhambra, Calif.) · 2021Article
- An Improved CMUT Structure Enabling Release and Collapse of the Plate in the Same Tx/Rx Cycle for Dual-Frequency Acoustic Angiography.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020Article
- Visualization of Microvascular Angiogenesis Using Dual-Frequency Contrast-Enhanced Acoustic Angiography: A Review.Ultrasound in medicine & biology · 2020Review
- Superharmonic Ultrasound for Motion-Independent Localization Microscopy: Applications to Microvascular Imaging From Low to High Flow Rates.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020Article
- Quantification of Morphological Features in Non-Contrast-Enhanced Ultrasound Microvasculature Imaging.IEEE access : practical innovations, open solutions · 2020Article
- Assessment of the Superharmonic Response of Microbubble Contrast Agents for Acoustic Angiography as a Function of Microbubble Parameters.Ultrasound in medicine & biology · 2019Article
- Ultrasound multiple scattering with microbubbles can differentiate between tumor and healthy tissue in vivo.Physics in medicine and biology · 2019Article
- Background Removal and Vessel Filtering of Noncontrast Ultrasound Images of Microvasculature.IEEE transactions on bio-medical engineering · 2019Article
- A Dual-Frequency Colinear Array for Acoustic Angiography in Prostate Cancer Evaluation.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2018Article
- Real-time ultrasound angiography using superharmonic dual-frequency (2.25MHz/30MHz) cylindrical array: In vitro study.Ultrasonics · 2018Article
- First-in-Human Study of Acoustic Angiography in the Breast and Peripheral Vasculature.Ultrasound in medicine & biology · 2017Article
- Dual-Frequency Piezoelectric Endoscopic Transducer for Imaging Vascular Invasion in Pancreatic Cancer.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2017Article
- Assessment of Molecular Acoustic Angiography for Combined Microvascular and Molecular Imaging in Preclinical Tumor Models.Molecular imaging and biology · 2017Article
- High Resolution Ultrasound Superharmonic Perfusion Imaging: In Vivo Feasibility and Quantification of Dynamic Contrast-Enhanced Acoustic Angiography.Annals of biomedical engineering · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Recently, dual-frequency transducers have enabled high-spatial-resolution and high-contrast imaging of vasculature with minimal tissue artifacts by transmitting at a low frequency and receiving broadband superharmonic echoes scattered by microbubble contrast agents. In this work, we examine the imaging parameters for optimizing contrast-to-tissue ratio (CTR) for dual-frequency imaging and the relationship with spatial resolution. Confocal piston transducers are used in a water bath setup to measure the SNR, CTR, and axial resolution for ultrasound imaging of nonlinear scattering of microbubble contrast agents when transmitting at a lower frequency (1.5 to 8 MHz) and receiving at a higher frequency (7.5 to 25 MHz). Parameters varied include the frequency and peak negative pressure of transmitted waves, center frequency of the receiving transducer, microbubble concentration, and microbubble size. CTR is maximized at the lowest transmission frequencies but would be acceptable for imaging in the 1.5 to 3.5 MHz range. At these frequencies, CTR is optimized when a receiving transducer with a center frequency of 10 MHz is used, with the maximum CTR of 25.5 dB occurring when transmitting at 1.5 MHz with a peak negative pressure of 1600 kPa and receiving with a center frequency of 10 MHz. Axial resolution is influenced more heavily by the receiving center frequency, with a weak decrease in measured pulse lengths associated with increasing transmit frequency. A microbubble population containing predominately 4-μm-diameter bubbles yielded the greatest CTR, followed by 1- and then 2-μm bubbles. Varying concentration showed little effect over the tested parameters. CTR dependence on transmit frequency and peak pressure were confirmed through in vivo imaging in two rodents. These findings may lead to improved imaging of vascular remodeling in superficial or luminal cancers such as those of the breast, prostate, and colon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.