Evidence map›Paper›PMID 25265168›Full record

ArticlePloS one2014

Inverse association between obesity predisposing FTO genotype and completed suicide.

Izabela Chojnicka, Sylwia Fudalej, Anna Walczak, Krystyna Wasilewska, Marcin Fudalej, Piotr Stawiński, Katarzyna Strawa, Aleksandra Pawlak, Marcin Wojnar, Paweł Krajewski and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Izabela ChojnickaDepartment of Medical Genetics, Medical University of Warsaw, Warsaw, Poland; Department of Rehabilitation Psychology, University of Warsaw, Warsaw, Poland.
Sylwia FudalejDepartment of Psychiatry, Medical University of Warsaw, Warsaw, Poland.
Anna WalczakDepartment of Medical Genetics, Medical University of Warsaw, Warsaw, Poland.
Krystyna WasilewskaDepartment of Medical Genetics, Medical University of Warsaw, Warsaw, Poland.
Marcin FudalejDepartment of Forensic Medicine, Medical University of Warsaw, Warsaw, Poland.
Piotr StawińskiDepartment of Medical Genetics, Medical University of Warsaw, Warsaw, Poland.
Katarzyna StrawaDepartment of Medical Genetics, Medical University of Warsaw, Warsaw, Poland.
Aleksandra PawlakDepartment of Forensic Medicine, Medical University of Warsaw, Warsaw, Poland.
Marcin WojnarDepartment of Psychiatry, Medical University of Warsaw, Warsaw, Poland; Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, United States of America.
Paweł KrajewskiDepartment of Forensic Medicine, Medical University of Warsaw, Warsaw, Poland.
Rafał PłoskiDepartment of Medical Genetics, Medical University of Warsaw, Warsaw, Poland.
Medical University of Warsaw · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The A allele of rs9939609 in the FTO gene predisposes to increased body mass index (BMI) and obesity. Recently we showed an inverse association between the obesity related A allele of rs9939609 and alcohol dependence which was replicated by others. Since this finding raises a possibility that FTO may be associated with other psychiatric phenotypes, we aimed to examine association of rs9939609 with completed suicide. We genotyped rs9939609 in 912 suicide victims and 733 controls using TaqMan approach. We observed an inverse association between suicide and the rs9939609 A allele (OR = 0.80, P = 0.002, Pcor = 0.006) with genotype distribution suggesting a co-dominant effect. Given the link between alcoholism and suicide under influence of alcohol reported in Polish population, confounding by alcohol addiction was unlikely due to apparently similar effect size among cases who were under influence of ethanol at the time of death (OR = 0.76, P = 0.003, N = 361) and those who were not (OR = 0.80, P = 0.007, N = 469). The search for genotype-phenotype correlations did not show significant results. In conclusion, our study proves that there is an inverse association between rs9939609 polymorphism in FTO gene and completed suicide which is independent from association between FTO and alcohol addiction.

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseaseSuicideAdultAlcoholismAllelesAlpha-Ketoglutarate-Dependent Dioxygenase FTOFemaleHumansMaleObesityPolymorphism, Single NucleotideProteinsAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanProteins

Identifiers

PMID25265168
PMCPMC4181953
OpenAlexW2027041608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.