Evidence map›Paper›PMID 25265078›Full record

ArticleAIDS (London, England)2014

Rates of HIV-1 superinfection and primary HIV-1 infection are similar in female sex workers in Uganda.

Andrew D Redd, Deogratius Ssemwanga, Judith Vandepitte, Sarah K Wendel, Nicaise Ndembi, Justine Bukenya, Susan Nakubulwa, Heiner Grosskurth, Chris M Parry, Craig Martens and 4 more

Abstract readComparative Study
In one paragraph

Article in AIDS (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
10.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Andrew D Redd *Laboratory of Immunoregulation, Division of Intramural Research, NIAID, NIH, Bethesda, USA.
Deogratius Ssemwanga *Medical Research Council/Uganda Virus Research Institute Research Unit on AIDS, Entebbe, Uganda.
Judith VandepitteMedical Research Council/Uganda Virus Research Institute Research Unit on AIDS, Entebbe, Uganda.
Sarah K WendelLaboratory of Immunoregulation, Division of Intramural Research, NIAID, NIH, Bethesda, USA.
Nicaise NdembiMedical Research Council/Uganda Virus Research Institute Research Unit on AIDS, Entebbe, Uganda.
Justine BukenyaMedical Research Council/Uganda Virus Research Institute Research Unit on AIDS, Entebbe, Uganda.
Susan NakubulwaMedical Research Council/Uganda Virus Research Institute Research Unit on AIDS, Entebbe, Uganda.
Heiner GrosskurthMedical Research Council/Uganda Virus Research Institute Research Unit on AIDS, Entebbe, Uganda.
Chris M ParryMedical Research Council/Uganda Virus Research Institute Research Unit on AIDS, Entebbe, Uganda.
Craig MartensGenomics Unit, Research Technologies Branch, Rocky Mountain Laboratories, Division of Intramural Research, NIAID, NIH, Hamilton MT, USA.
Daniel BrunoGenomics Unit, Research Technologies Branch, Rocky Mountain Laboratories, Division of Intramural Research, NIAID, NIH, Hamilton MT, USA.
Stephen F PorcellaGenomics Unit, Research Technologies Branch, Rocky Mountain Laboratories, Division of Intramural Research, NIAID, NIH, Hamilton MT, USA.
Thomas C QuinnLaboratory of Immunoregulation, Division of Intramural Research, NIAID, NIH, Bethesda, USA.
Pontiano KaleebuMedical Research Council/Uganda Virus Research Institute Research Unit on AIDS, Entebbe, Uganda.
Uganda Virus Research Institute · UGJohns Hopkins Medicine · USJohns Hopkins University · USNational Institute of Allergy and Infectious Diseases · US

Funding

International Studies of the Acquired Immune Deficiency Syndrome (AIDS)ZIAAI000361 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REDD, ANDREW · 2009 to 2025
$15.8M
IMMUNOLOGICAL AND VIRAL FACTORS ASSOCIATED WITH HIV-1 SUPERINFECTIONR01AI118368 · NIAID · UGANDA VIRUS RESEARCH INSTITUTE · PI KALEEBU, PONTIANO · 2015 to 2019
$677k
Intramural NIH HHS Z99 AI999999Medical Research Council MC_UP_1204/2NIAID NIH HHS R01 AI118368Wellcome TrustWellcome Trust 084344
6 · The paper itself

Abstract

objectiveTo determine and compare the rates of HIV superinfection and primary HIV infection in high-risk female sex workers (FSWs) in Kampala, Uganda.

designA retrospective analysis of individuals who participated in a clinical cohort study among high-risk FSWs in Kampala, Uganda.

methodsPlasma samples from HIV-infected FSWs in Kampala, Uganda were examined with next-generation sequencing of the p24 and gp41 HIV genomic regions for the occurrence of superinfection. Primary HIV incidence was determined from initially HIV-uninfected FSWs from the same cohort, and incidence rate ratios were compared.

resultsThe rate of superinfection in these women (7/85; 3.4/100 person-years) was not significantly different from the rate of primary infection in the same population (3.7/100 person-years; incidence rate ratio = 0.91, P = 0.42). Seven women also entered the study dual-infected (16.5% either dual or superinfected). The women with any presence of dual infection were more likely to report sex work as their only source of income (P = 0.05), and trended to be older and more likely to be widowed (P = 0.07).

conclusionsIn this cohort of FSWs, HIV superinfection occurred at a high rate and was similar to that of primary HIV infection. These results differ from a similar study of high-risk female bar workers in Kenya that found the rate of superinfection to be significantly lower than the rate of primary HIV infection.

Indexed as

HIV-1HIV InfectionsSexual PartnersSuperinfectionAdultAge FactorsCohort StudiesDisease ProgressionFemaleFollow-Up StudiesHumansIncidenceRetrospective StudiesSex WorkersUgandaViral Load

Identifiers

PMID25265078
PMCPMC4921228
OpenAlexW2064625714

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.