ArticlePloS one2014
Multivariate longitudinal shape analysis of human lateral ventricles during the first twenty-four months of life.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Infant and Child MRI: A Review of Scanning Procedures.Frontiers in neuroscience · 2021Review
- Measurement of lateral ventricle volume of normal infant based on magnetic resonance imaging.Chinese neurosurgical journal · 2019Article
- Visualization of the periventricular Virchow-Robin spaces with ependymal openings.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- Imaging structural and functional brain development in early childhood.Nature reviews. Neuroscience · 2018Review
- Biomechanical Analysis of Normal Brain Development during the First Year of Life Using Finite Strain Theory.Scientific reports · 2016Article
- Article
- Interpolation of Longitudinal Shape and Image Data via Optimal Mass Transport.Proceedings of SPIE--the International Society for Optical Engineering · 2014Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundLittle is known about the temporospatial shape characteristics of human lateral ventricles (LVs) during the first two years of life. This study aimed to delineate the morphological growth characteristics of LVs during early infancy using longitudinally acquired MR images in normal healthy infants.
methods24 healthy infants were MR imaged starting from 2 weeks old every 3 months during the first and every 6 months during the second year. Bilateral LVs were segmented and longitudinal morphological and shape analysis were conducted using longitudinal mixed effect models.
resultsA significant bilateral ventricular volume increase (p<0.0001) is observed in year one (Left: 126±51% and Right: 145±62%), followed by a significant reduction (p<0.02) during the second year of life (Left: -24±27% and Right: -20±18%) despite the continuing increase of intracranial volume. Morphological analysis reveals that the ventricular growth is spatially non-uniform, and that the most significant growth occurs during the first 6 months. The first 3 months of life exhibit a significant (p<0.01) bilateral lengthening of the anterior lateral ventricle and a significant increase of radius (p<0.01) and area (p<0.01) at the posterior portion of the ventricle. Shape analysis shows that the horns exhibit a faster growth rate than the mid-body. Finally, bilateral significant age effects (p<0.01) are observed for the growth of LVs whereas gender effects are more subtle and significant effects (p<0.01) only present at the left anterior and posterior horns. More importantly, both the age and gender effects are growth directionally dependent.
conclusionsWe have demonstrated the temporospatial shape growth characteristics of human LVs during the first two years of life using a unique longitudinal MR data set. A temporally and spatially non-uniform growth pattern was reported. These normative results could provide invaluable information to discern abnormal growth patterns in patients with neurodevelopmental disorders.
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