Trial reportPsychosomatic medicine2014
Omega-3 supplementation and loneliness-related memory problems: secondary analyses of a randomized controlled trial.
Trial report in Psychosomatic medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00385723 (Omega-3 Dietary Supplementation, Immune Function, and Mood), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Omega-3 Dietary Supplementation, Immune Function, and Mood
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Docosahexaenoic acid supplementation in age-related cognitive decline: a systematic review and meta-analysis.European journal of clinical pharmacology · 2020Pooled it
- Brain Health across the Lifespan: A Systematic Review on the Role of Omega-3 Fatty Acid Supplements.Nutrients · 2018Pooled it
- Twelve Weeks of Additional Fish Intake Improves the Cognition of Cognitively Intact, Resource-Limited Elderly People: A Randomized Control Trial.The journal of nutrition, health & aging · 2022Trial
- Trial
- Psychoneuroimmunology and the research of Janice Kiecolt-Glaser: It informs self-care and the practice of medicine.Comprehensive psychoneuroendocrinology · 2024Review
- Moving toward affective immunology: Legacy and future directions.Comprehensive psychoneuroendocrinology · 2024Article
- Effects of Omega-3 Polyunsaturated Fatty Acids on Brain Functions: A Systematic Review.Cureus · 2022Review
- Maternal Supply of Both Arachidonic and Docosahexaenoic Acids Is Required for Optimal Neurodevelopment.Nutrients · 2021Review
- Dietary Sources of Omega-3 Fatty Acids Versus Omega-3 Fatty Acid Supplementation Effects on Cognition and Inflammation.Current nutrition reports · 2020Review
- Docosahexaenoic Acid and Cognition throughout the Lifespan.Nutrients · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveLoneliness enhances risk for episodic memory declines over time. Omega-3 supplementation can improve cognitive function for people experiencing mild cognitive difficulties. Accordingly, we explored whether omega-3 supplementation would attenuate loneliness-related episodic memory problems.
methodsParticipants (n = 138) from a parent randomized controlled trial were randomized to the placebo, 1.25 grams/d of omega-3, or 2.50 grams/d of omega-3 conditions for a 4-month period. They completed a baseline loneliness questionnaire and a battery of cognitive tests both at baseline and at the end of the randomized controlled trial.
resultsAfter adjustment for baseline verbal episodic memory scores, lonelier people within the placebo condition had poorer verbal episodic memory postsupplementation, as measured by immediate (b = -0.28, t (117) = -2.62, p = .010) and long-delay (b = -0.06, t (116) = -2.07, p = .040) free recall, than their less lonely counterparts. This effect was not observed in the 1.25- and 2.50-grams/d supplementation groups (all p values > .10). The plasma omega-6:omega-3 ratio data mirrored these results. There were no loneliness-related effects of omega-3 supplementation on short-delay recall or the other cognitive tests (all p values > .32).
conclusionThese results suggest that omega-3 supplementation attenuates loneliness-related verbal episodic memory declines over time and support the use of exploring novel interventions for treating episodic memory problems among lonely people.
trial registrationclinicaltrials.gov Identifier: NCT00385723.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.