Evidence map›Paper›PMID 25264760›Full record

ArticlePloS one2014

Association of HLA class-I and inhibitory KIR genotypes in Gabonese patients infected by Chikungunya or Dengue type-2 viruses.

Caroline Petitdemange, Nadia Wauquier, Jean-Michel Jacquet, Ioannis Theodorou, Eric Leroy, Vincent Vieillard

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

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  13. Cellular and Molecular Immune Response to Chikungunya Virus Infection.Frontiers in cellular and infection microbiology · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Caroline PetitdemangeSorbonne Universités, UPMC, Univ Paris 06, CR7, CIMI-Paris, Paris, France; INSERM, U1135, CIMI-Paris, Paris, France; Centre International de Recherches Médicales de Franceville, Unité des maladies Emergentes, Franceville, Gabon.
Nadia WauquierSorbonne Universités, UPMC, Univ Paris 06, CR7, CIMI-Paris, Paris, France; Metabiota Inc., San Francisco, California, United States of America.
Jean-Michel JacquetAP-HP Hôpital Pitié-Salpêtrière, Département d'Immunologie, Paris, France.
Ioannis TheodorouSorbonne Universités, UPMC, Univ Paris 06, CR7, CIMI-Paris, Paris, France; INSERM, U1135, CIMI-Paris, Paris, France; AP-HP Hôpital Pitié-Salpêtrière, Département d'Immunologie, Paris, France.
Eric LeroyCentre International de Recherches Médicales de Franceville, Unité des maladies Emergentes, Franceville, Gabon; IRD, Maladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle, Montpellier, France.
Vincent VieillardSorbonne Universités, UPMC, Univ Paris 06, CR7, CIMI-Paris, Paris, France; INSERM, U1135, CIMI-Paris, Paris, France; CNRS, ERL8255, CIMI-Paris, Paris, France.
Centre d'Immunologie et des Maladies Infectieuses · FRMaladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle · FRMetabiota (United States) · USPitié-Salpêtrière Hospital · FRSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNatural killer (NK) cells provide defense in the early stages of the immune response against viral infections. Killer cell immunoglobulin-like receptors (KIR) expressed on the surface of NK cells play an important role in regulating NK cell response through recognition of human leukocyte antigen (HLA) class I molecules on target cells. Previous studies have shown that specific KIR/ligand combinations are associated with the outcome of several viral infectious diseases.

methodsWe investigated the impact of inhibitory and activating KIR and their HLA-class I ligand genotype on the susceptibility to Chikungunya virus (CHIKV) and Dengue virus (DENV2) infections. From April to July 2010 in Gabon, a large outbreak of CHIKV and DENV2 concomitantly occurred in two provinces of Gabon (Ogooué-Lolo and Haut-Ogooué). We performed the genotypic analysis of KIR in the combination with their cognate HLA-class I ligands in 73 CHIKV and 55 DENV2 adult cases, compared with 54 healthy individuals.

resultsWe found in CHIV-infected patients that KIR2DL1 and KIR2DS5 are significantly increased and decreased respectively, as compared to DENV2+ patients and healthy donors. The combination of KIR2DL1 and its cognate HLA-C2 ligand was significantly associated with the susceptibility to CHIKV infection. In contrast, no other inhibitory KIR-HLA pairs showed an association with the two mosquito-borne arboviruses.

conclusionThese observations are strongly suggestive that the NK cell repertoire shaped by the KIR2DL1:HLA-C2 interaction facilitate specific infection by CHIKV.

Indexed as

Genetic Predisposition to DiseaseAdultCase-Control StudiesChikungunya FeverChikungunya virusDengueDengue VirusFemaleGabonGene FrequencyGenetic Association StudiesGenetic VariationHistocompatibility Antigens Class IHumansLigandsMaleHistocompatibility Antigens Class ILigandsReceptors, KIR

Identifiers

PMID25264760
PMCPMC4181859
OpenAlexW1998020450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.