ArticleTranslational behavioral medicine2014
Introduction to SMART designs for the development of adaptive interventions: with application to weight loss research.
Article in Translational behavioral medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 256 papers, 10 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics
Identifying an Effective and Cost Beneficial Approach to Preventing OUD in Justice-Involved Youth
RADx Up Safe Return to Schools: Strategies to Increase Vaccine Uptake
Precision Medicine in Alzheimer's Disease: A SMART Trial of Adaptive Exercises and Their Mechanisms of Action Using AT(N) Biomarkers to Optimize Aerobic-Fitness Responses (The FIT-AD SMART Trial)
Comparative Effectiveness of Pharmacologic Management of ADHD in Children and Youth With Autism Spectrum Disorder
Who cites it
256 citing papers in PubMed, 10 syntheses or guidelines pooled it, 441 citations in OpenAlex.
- The use of sequential multiple assignment randomized trials (SMARTs) in physical activity interventions: a systematic review.BMC medical research methodology · 2024Pooled it
- Use of Sequential Multiple Assignment Randomized Trials (SMARTs) in oncology: systematic review of published studies.British journal of cancer · 2023Pooled it
- Individualized interventions and precision health: Lessons learned from a systematic review and implications for analytics-driven geriatric research.Journal of the American Geriatrics Society · 2023Pooled it
- Integrated Behavioral Interventions for Adults with Comorbid Obesity and Depression: a Systematic Review.Current diabetes reports · 2022Pooled it
- A Decade in Review: A Systematic Review of Virtual Reality Interventions for Emotional Disorders.Psychosocial intervention · 2022Pooled it
- Harnessing technological solutions for childhood obesity prevention and treatment: a systematic review and meta-analysis of current applications.International journal of obesity (2005) · 2021Pooled it
- Understanding the Effects of Naturalistic Developmental Behavioral Interventions: A Project AIM Meta-analysis.Autism research : official journal of the International Society for Autism Research · 2021Pooled it
- Quantitative Evidence Synthesis Methods for the Assessment of the Effectiveness of Treatment Sequences for Clinical and Economic Decision Making: A Review and Taxonomy of Simplifying Assumptions.PharmacoEconomics · 2021Pooled it
- A systematic review of mHealth interventions for HIV prevention and treatment among gay, bisexual, and other men who have sex with men.Translational behavioral medicine · 2020Pooled it
- A Systematic Review of Technology-Assisted HIV Testing Interventions.Current HIV/AIDS reports · 2020Pooled it
- Skills Training in Affective Recovery Video and Text Programs for Recent Sexual Assault Survivors: A Pilot Randomized Clinical Trial.JAMA network open · 2026Trial
- Adaptive, Stepped-Care for Cancer-Related PTSD Symptoms in HCT Survivors: Results From a SMART Trial.Psycho-oncology · 2026Trial
- Digital Mental Health Treatment and Symptoms of Depression and Anxiety in Breast Cancer Survivors: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Feasibility of an Adaptive Food Insecurity Intervention for Patients with Uncontrolled Hypertension: A Pilot SMART.Population health management · 2026Trial
- Prevention of urinary stones with hydration: a randomised clinical trial of an adherence intervention.Lancet (London, England) · 2026Trial
- The Adaptive Physical Activity Study in Stroke (TAPAS): A Feasibility Sequential Multiple Assignment Randomized Trial.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Trial
- Characteristics associated with medication adherence in a randomized clinical trial of multiple pharmacotherapy adaptations based on treatment response in black adults who smoke.Addictive behaviors · 2025Trial
- Adaptive dietary and exercise strategies for weight loss in Adults with Prediabetes Trial (ADAPT): a sequential multiple assignment randomized trial.The American journal of clinical nutrition · 2025Trial
- Clinical and Patient-Reported Outcomes in Grade III Furcations: A Randomized Feasibility Trial With SMART Design.Journal of clinical periodontology · 2025Trial
- Working Women Walking Program: A Sequential Multiple Assignment Randomized Trial.Journal of physical activity & health · 2025Trial
196 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The management of many health disorders often entails a sequential, individualized approach whereby treatment is adapted and readapted over time in response to the specific needs and evolving status of the individual. Adaptive interventions provide one way to operationalize the strategies (e.g., continue, augment, switch, step-down) leading to individualized sequences of treatment. Often, a wide variety of critical questions must be answered when developing a high-quality adaptive intervention. Yet, there is often insufficient empirical evidence or theoretical basis to address these questions. The Sequential Multiple Assignment Randomized Trial (SMART)-a type of research design-was developed explicitly for the purpose of building optimal adaptive interventions by providing answers to such questions. Despite increasing popularity, SMARTs remain relatively new to intervention scientists. This manuscript provides an introduction to adaptive interventions and SMARTs. We discuss SMART design considerations, including common primary and secondary aims. For illustration, we discuss the development of an adaptive intervention for optimizing weight loss among adult individuals who are overweight.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.