Evidence map›Paper›PMID 25264359›Full record

ArticleGenesis (New York, N.Y. : 2000)2014

In vivo visualization of the development of the enteric nervous system using a Tg(-8.3bphox2b:Kaede) transgenic zebrafish.

Colin Harrison, Tara Wabbersen, Iain T Shepherd

Open access · greenAbstract read
In one paragraph

Article in Genesis (New York, N.Y. : 2000), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Review
  4. BMP signaling pathway member expression is enriched in enteric neural progenitors and required for zebrafish enteric nervous system development.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Development (Cambridge, England) · 2020
    Article
  17. Review
  18. Article
  19. Article
  20. Molecular fingerprinting delineates progenitor populations in the developing zebrafish enteric nervous system.Developmental dynamics : an official publication of the American Association of Anatomists · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Colin HarrisonDepartment of Biology, Emory University, Atlanta, Georgia.
Tara Wabbersen
Iain T Shepherd
Emory University · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008490 · NIGMS · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 1993 to 2022
$8.0M
Analysis of HSCR patient exome sequence data using ZebrafishR21NS082546 · NINDS · EMORY UNIVERSITY · PI SHEPHERD, IAIN T · 2013 to 2014
$394k
NIGMS NIH HHS 5T332GM008490-22NINDS NIH HHS R21 NS082546
6 · The paper itself

Abstract

The phox2b gene encodes a transcription factor that is expressed in the developing enteric nervous system (ENS). An enhancer element has been identified in the zebrafish phox2b locus that can drive tissue specific expression of reporter genes in enteric neuron precursor cells. We have generated a transgenic zebrafish line in which the Kaede fluorescent protein is under the control of this phox2b enhancer. This line has stable expression of the Kaede protein in enteric neuron precursor cells over three generations. To demonstrate the utility of this line we compared the migration and division rates of enteric neuron precursor cells in wild type and the zebrafish ENS mutant lessen.

Indexed as

Animals, Genetically ModifiedAnimalsEnhancer Elements, GeneticEnteric Nervous SystemHomeodomain ProteinsLuminescent ProteinsMaleOrgan SpecificityTranscription FactorsZebrafishZebrafish ProteinsHomeodomain ProteinsLuminescent ProteinsNBPhox proteinTranscription FactorsZebrafish Proteinsenteric nervous systemin vivoKaedemed24phox2b

Identifiers

PMID25264359
PMCPMC5804488
OpenAlexW1569530645

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.