ArticleSmall (Weinheim an der Bergstrasse, Germany)2015
A multifunctional nanoplatform for imaging, radiotherapy, and the prediction of therapeutic response.
Article in Small (Weinheim an der Bergstrasse, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Golden era of radiosensitizers.Frontiers in veterinary science · 2024Pooled it
- Long-Term Biodistribution of FeInternational journal of molecular sciences · 2026Article
- Current approaches in smart nano-inspired drug delivery: A narrative review.Health science reports · 2024Article
- Recent Advances in Metal-Based NanoEnhancers for Particle Therapy.Nanomaterials (Basel, Switzerland) · 2023Review
- AntiPD-L1 antibody conjugated Au-SPIOs nanoplatform for enhancing radiosensitivity and triggering anti-tumor immune response.Scientific reports · 2022Article
- Nanoparticle-assisted, image-guided laser interstitial thermal therapy for cancer treatment.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2022Review
- Clinical Feasibility Study of Gold Nanoparticles as Theragnostic Agents for Precision Radiotherapy.Biomedicines · 2022Article
- Going even smaller: Engineering sub-5 nm nanoparticles for improved delivery, biocompatibility, and functionality.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020Review
- Nanoparticle contrast agents for X-ray imaging applications.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020Review
- Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects.Nanomaterials (Basel, Switzerland) · 2020Review
- Biodegradable Gold Nanoclusters with Improved Excretion Due to pH-Triggered Hydrophobic-to-Hydrophilic Transition.Journal of the American Chemical Society · 2020Article
- Fundamentals to clinical application of nanoparticles in cancer immunotherapy and radiotherapy.Ecancermedicalscience · 2020Review
- Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2019Review
- Indocyanine Green-Coated Gold Nanoclusters for Photoacoustic Imaging and Photothermal Therapy.Advanced therapeutics · 2019Article
- Protoporphyrin IX (PpIX)-Coated Superparamagnetic Iron Oxide Nanoparticle (SPION) Nanoclusters for Magnetic Resonance Imaging and Photodynamic Therapy.Advanced functional materials · 2018Article
- The Development of a Nano-based Approach to Alleviate Cisplatin-Induced Ototoxicity.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Dual radiosensitization and anti-STAT3 anti-proliferative strategy based on delivery of gold nanoparticle - oligonucleotide nanoconstructs to head and neck cancer cells.Nanotheranostics · 2018Article
- Metal-basedTheranostics · 2018Review
- Photoacoustic-Guided Surgery with Indocyanine Green-Coated Superparamagnetic Iron Oxide Nanoparticle Clusters.Small (Weinheim an der Bergstrasse, Germany) · 2017Article
- Targeted nanoparticles for tumour radiotherapy enhancement-the long dawn of a golden era?Annals of translational medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
Gold nanoparticles have garnered interest as both radiosensitzers and computed tomography (CT) contrast agents. However, the extremely high concentrations of gold required to generate CT contrast is far beyond that needed for meaningful radiosensitization, which limits their use as combined therapeutic-diagnostic (theranostic) agents. To establish a theranostic nanoplatform with well-aligned radiotherapeutic and diagnostic properties for better integration into standard radiation therapy practice, a gold- and superparamagnetic iron oxide nanoparticle (SPION)-loaded micelle (GSM) is developed. Intravenous injection of GSMs into tumor-bearing mice led to selective tumoral accumulation, enabling magnetic resonance (MR) imaging of tumor margins. Subsequent irradiation leads to a 90-day survival of 71% in GSM-treated mice, compared with 25% for irradiation-only mice. Furthermore, measurements of the GSM-enhanced MR contrast are highly predictive of tumor response. Therefore, GSMs may not only guide and enhance the efficacy of radiation therapy, but may allow patients to be managed more effectively.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.