ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2015
Muscle torque relative to cross-sectional area and the functional muscle-bone unit in children and adolescents with chronic disease.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06624358 (Physical Activity in Adolescents With Chronic Kidney Disease), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physical Activity in Adolescents With Chronic Kidney Disease
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Meta-analyses of the quantitative computed tomography data in dialysis patients show differential impacts of renal failure on the trabecular and cortical bones.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Pooled it
- Effect of Low-Magnitude Mechanical Stimuli on Bone Density and Structure in Pediatric Crohn's Disease: A Randomized Placebo-Controlled Trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Trial
- Improvements in Bone Density and Structure during Anti-TNF-α Therapy in Pediatric Crohn's Disease.The Journal of clinical endocrinology and metabolism · 2015Trial
- Gut, bone, and muscle: the triad of osteosarcopenia in inflammatory bowel disease.Intestinal research · 2025Review
- Article
- Balance in children with chronic kidney disease: the relationship between skeletal muscle mass index, fatigue, and physical function.Pediatric nephrology (Berlin, Germany) · 2025Article
- Creating a digital approach for promoting physical activity in pediatric pulmonary hypertension: A framework for future interventions.Pulmonary circulation · 2024Article
- Scoping review on health-related physical fitness in patients with inflammatory bowel disease: Assessment, interventions, and future directions.World journal of gastroenterology · 2023Article
- Malnutrition Patterns in Children with Chronic Kidney Disease.Life (Basel, Switzerland) · 2023Review
- Treatment of cystic fibrosis related bone disease.Journal of clinical & translational endocrinology · 2022Article
- Skeletal muscle deficits are associated with worse exercise performance in pediatric pulmonary hypertension.Frontiers in pediatrics · 2022Article
- Muscle-bone axis in children with chronic kidney disease: current knowledge and future perspectives.Pediatric nephrology (Berlin, Germany) · 2021Review
- A narrative review of skeletal muscle atrophy in critically ill children: pathogenesis and chronic sequelae.Translational pediatrics · 2021Review
- Sarcopenia and preserved bone mineral density in paediatric survivors of high-risk neuroblastoma with growth failure.Journal of cachexia, sarcopenia and muscle · 2021Article
- The Association of Diet and Exercise With Body Composition in Pediatric Crohn's Disease.Inflammatory bowel diseases · 2018Observational
- Muscle-Bone Interactions in Pediatric Bone Diseases.Current osteoporosis reports · 2017Review
- Body composition estimation using skinfolds in children with and without health conditions affecting growth and body composition.Annals of human biology · 2017Article
- Update on Bone Health in Pediatric Chronic Disease.Endocrinology and metabolism clinics of North America · 2016Review
- Physical activity and screen time in adolescents in the chronic kidney disease in children (CKiD) cohort.Pediatric nephrology (Berlin, Germany) · 2016Article
- Reduced skeletal muscle function is associated with decreased fiber cross-sectional area in the Cy/+ rat model of progressive kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2016Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Measures of muscle mass or size are often used as surrogates of forces acting on bone. However, chronic diseases may be associated with abnormal muscle force relative to muscle size. The muscle-bone unit was examined in 64 children and adolescents with new-onset Crohn's disease (CD), 54 with chronic kidney disease (CKD), 51 treated with glucocorticoids for nephrotic syndrome (NS), and 264 healthy controls. Muscle torque was assessed by isometric ankle dynamometry. Calf muscle cross-sectional area (CSA) and tibia cortical section modulus (Zp) were assessed by quantitative CT. Log-linear regression was used to determine the relations among muscle CSA, muscle torque, and Zp, adjusted for tibia length, age, Tanner stage, sex, and race. Muscle CSA and muscle torque-relative-to-muscle CSA were significantly lower than controls in advanced CKD (CSA -8.7%, p = 0.01; torque -22.9%, p < 0.001) and moderate-to-severe CD (CSA -14.1%, p < 0.001; torque -7.6%, p = 0.05), but not in NS. Zp was 11.5% lower in advanced CKD (p = 0.005) compared to controls, and this deficit was attenuated to 6.7% (p = 0.05) with adjustment for muscle CSA. With additional adjustment for muscle torque and body weight, Zp was 5.9% lower and the difference with controls was no longer significant (p = 0.09). In participants with moderate-to-severe CD, Zp was 6.8% greater than predicted (p = 0.01) given muscle CSA and torque deficits (R(2) = 0.92), likely due to acute muscle loss in newly-diagnosed patients. Zp did not differ in NS, compared with controls. In conclusion, muscle torque relative to muscle CSA was significantly lower in CKD and CD, compared with controls, and was independently associated with Zp. Future studies are needed to determine if abnormal muscle strength contributes to progressive bone deficits in chronic disease, independent of muscle area. © 2014 American Society for Bone and Mineral Research.
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