ArticleJournal of cutaneous pathology2014
Desmosomal defects in acantholytic squamous cell carcinomas.
Article in Journal of cutaneous pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Acantholytic plaque on the right breast.JAAD case reports · 2026Article
- Acantholytic squamous cell carcinoma of the lung with pseudoglandular features: clinicopathologic study of 14 cases.Virchows Archiv : an international journal of pathology · 2025Article
- Desmocollin-1 is associated with pro-metastatic phenotype of luminal A breast cancer cells and is modulated by parthenolide.Cellular & molecular biology letters · 2023Article
- Acantholytic oral squamous cell carcinoma with clear cell change - a rare amalgamated variant.Autopsy & case reports · 2023Article
- Adenoid (Acantholytic) Squamous Cell Carcinoma of Mandibular Gingiva.Case reports in dentistry · 2021Article
- RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis.PLoS genetics · 2019Article
- Desmosomes in acquired disease.Cell and tissue research · 2015Review
- Vulvar cancer: a review for dermatologists.Wiener medizinische Wochenschrift (1946) · 2015Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAcantholytic squamous cell carcinoma (Acantholytic SCC) are epithelial tumors characterized by a loss of cell adhesion between neoplastic keratinocytes. The mechanism underlying loss of cell-cell adhesion in these tumors is not understood.
methodsA retrospective analysis of acantholytic SCC (n = 17) and conventional SCC (n = 16, controls not showing acantholysis) was conducted using a set of desmosomal and adherens junction protein antibodies. Immunofluorescence microscopy was used to identify tumors with loss of adhesion protein expression.
resultsThe vast majority of acantholytic SCC (89%) showed focal loss of at least one desmosomal cell adhesion protein. Most interestingly, 65% of these tumors lost expression of two or more desmosomal proteins.
conclusionsLoss of cell adhesion in acantholytic SCC is most likely linked to the focal loss of desmosomal protein expression, thus providing potential mechanistic insight into the patho-mechanism underlying this malignancy.
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