ArticleThe Laryngoscope2015
Complications following primary and revision transsphenoidal surgeries for pituitary tumors.
Article in The Laryngoscope, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 36 citations in OpenAlex.
- Endoscopic endonasal approach for recurrent or residual pituitary neuroendocrine tumors.Neurosurgical review · 2026Article
- Social Determinants of Health in Endoscopic Anterior Skull Base Surgery: A Systematic Review and Meta-Analysis.Laryngoscope investigative otolaryngology · 2025Review
- Real-time intraoperative ultrasound imaging of the posterior pituitary gland during endoscopic endonasal approach.Acta neurochirurgica · 2024Article
- A Comprehensive Analysis of Tobacco Smoking History as a Risk for Outcomes after Endoscopic Transsphenoidal Resection of Pituitary Adenoma.Journal of neurological surgery. Part B, Skull base · 2024Article
- Risk Factors Associated with Postoperative CSF Leak in Extrasellar Tumors.Journal of neurological surgery. Part B, Skull base · 2024Article
- Prognostic indicators in pituitary adenoma surgery: a comprehensive analysis of surgical outcomes and complications.Frontiers in endocrinology · 2023Article
- Preliminary Comparison of Transseptal Microscopic Versus Endoscopic Transsphenoidal Surgery in a University Teaching Hospital.The Malaysian journal of medical sciences : MJMS · 2022Article
- Comparative study of complications after primary and revision transsphenoidal endoscopic surgeries.Neurosurgical review · 2021Article
- Use of Ultrasound for Navigating the Internal Carotid Artery in Revision Endoscopic Endonasal Skull Base Surgery.Cureus · 2021Article
- National trends in hospital readmission following transsphenoidal surgery for pituitary lesions.Pituitary · 2020Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectives/hypothesisThis study aimed to determine the incidence of major complications following both primary and revision transsphenoidal pituitary surgery. Major complications included endocrinopathic, skull base, orbital, hemorrhagic and thromboembolic complications, respiratory failure, and death. Secondarily, this study aimed to examine factors associated with the occurrence of complications. STUDY
designRetrospective cohort analysis of California and Florida all-payer databases from 2005 to 2008.
methodsThe major complication rate following both primary and revision transsphenoidal pituitary surgery was calculated. Bivariate analyses were performed to investigate the relationship of patient characteristics with complication occurrence, and a multivariate model was constructed to determine risk factors associated with these complications.
resultsThere were 5,277 primary cases and 192 revision cases that met inclusion criteria. There was a nonsignificant absolute difference of 3.09% (95% confidence interval [CI]: -11.00 to 16.14) between the rate of complications following primary (n = 443, 8.39%) and revision (n = 22, 11.46%) surgeries. Multivariate analyses showed that patients with Medicare (odds ratio [OR]:1.74, 95% CI: 1.17 to 2.61), Medicaid (OR: 2.13, 95% CI: 1.59 to 2.86), or a malignant neoplasm (OR: 3.10, 95% CI: 1.62 to 5.93) were more likely to have complications.
conclusionsThe rate of major complications following transsphenoidal pituitary surgery is lower than earlier retrospective reports. The overall complication rate following revision surgery was not significantly different from primary surgery. Insurance status and a diagnosis of a malignant neoplasm were associated with a higher rate of complications. LEVEL OF EVIDENCE: 2C.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.