ArticleJournal of hospital medicine2015
Hospital outcomes associated with guideline-recommended antibiotic therapy for pediatric pneumonia.
Article in Journal of hospital medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Dosing Recommendations for Ampicillin and Ceftriaxone in the Treatment of Pediatric Community-Acquired Pneumonia Using Monte Carlo- and Physiologic-Based Pharmacokinetic Simulations.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025Article
- Epidemiology and mortality predictors for severe childhood community-acquired pneumonia in ICUs: A retrospective observational study.Frontiers in pediatrics · 2023Article
- Identifying Potentially Unnecessary Hospitalizations in Children With Pneumonia.Hospital pediatrics · 2022Article
- Combined influence of practice guidelines and prospective audit and feedback stewardship on antimicrobial treatment of community-acquired pneumonia and empyema in children: 2012 to 2016.Paediatrics & child health · 2021Article
- Improving antibiotic prescribing in the emergency department for uncomplicated community-acquired pneumonia.World journal of emergency medicine · 2020Article
- Treatment of Community-Acquired Pneumonia: Are All Countries Treating Children in the Same Way? A Literature Review.International journal of pediatrics · 2017Review
- Recent Developments in Pediatric Community-Acquired Pneumonia.Current infectious disease reports · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundRecent national guidelines recommend use of narrow-spectrum antibiotic therapy as empiric treatment for children hospitalized with community-acquired pneumonia (CAP). However, clinical outcomes associated with adoption of this recommendation have not been studied.
methodsThis retrospective cohort study included children age 3 months to 18 years, hospitalized with CAP from May 2, 2011 through July 30, 2012. Primary exposure of interest was empiric antibiotic therapy, classified as guideline recommended or not. Primary outcomes were length of stay (LOS), total hospital costs, and inpatient pharmacy costs. Secondary outcomes included broadened antibiotic therapy, emergency department revisits, and readmissions. Multivariable linear regression and Fisher exact test were performed to determine the association of guideline-recommended antibiotic therapy on outcomes.
resultsEmpiric guideline-recommended therapy was prescribed to 168 (76%) of 220 patients. Median hospital LOS was 1.3 days (interquartile range [IQR]: 0.9-1.9 days), median total cost of index hospitalization was $4097 (IQR: $2657-$6054), and median inpatient pharmacy cost was $91 (IQR: $40-$183). Between patients who did and did not receive guideline-recommended therapy, there were no differences in LOS (adjusted -5.8% change; 95% confidence interval [CI]: -22.1 to 12.8), total costs (adjusted -10.9% change; 95% CI: -27.4 to 9.4), or inpatient pharmacy costs (adjusted 14.8% change; 95% CI: -43.4 to 27.1). Secondary outcomes were rare, with no difference in unadjusted analysis between patients who did and did not receive guideline-recommended therapy.
conclusionsUse of guideline-recommended antibiotic therapy was not associated with unintended negative consequences; there were no changes in LOS, total costs, or inpatient pharmacy costs.
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