ReviewExperimental neurology2015
Epigenetic mechanisms of neuroplasticity and the implications for stroke recovery.
Review in Experimental neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Flexible exoskeleton-assisted training enhances lower limb motor function after stroke: a systematic review and meta-analysis.Journal of neurology · 2025Pooled it
- Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies.International journal of molecular sciences · 2017Pooled it
- Electroacupuncture combined with rTMS promotes neuronal regenerationEuropean journal of histochemistry : EJH · 2026Article
- Genome-Wide DNA Methylation Profiling Reveals Low Methylation Variability in Moyamoya Disease.Translational stroke research · 2025Article
- Environmental enrichment: a neurostimulatory approach to aging and ischemic stroke recovery and rehabilitation.Biogerontology · 2025Review
- Edaravone dextrocamphorol combined with intravenous thrombolysis enhances recovery in acute ischemic stroke.American journal of translational research · 2025Article
- Impact of Histone Acetyltransferases and Histone Deacetylases on Adult Brain Myelin Plasticity.Results and problems in cell differentiation · 2025Review
- Article
- Modalization and Transcendence of Health in the Coming Decade: Emphasizing the Human Cognitive System in the Stories of Prophets in the Holy Quran.Iranian journal of medical sciences · 2024Review
- A Review of Current Perspectives on Motoric Insufficiency Rehabilitation following Pediatric Stroke.Healthcare (Basel, Switzerland) · 2024Review
- X, but not Y, Chromosomal Complement Contributes to Stroke Sensitivity in Aged Animals.Translational stroke research · 2023Article
- Exploring the transformative influence of neuroplasticity on stroke rehabilitation: a narrative review of current evidence.Annals of medicine and surgery (2012) · 2023Review
- Brain Analysis with a Complex Network Approach in Stroke Patients Based on Electroencephalography: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2023Review
- HTRA1 methylation in peripheral blood as a potential marker for the preclinical detection of stroke: a case-control study and a prospective nested case-control study.Clinical epigenetics · 2022Article
- The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer's Disease Mouse Model.Brain sciences · 2022Article
- The Role of DNA Methylation in Stroke Recovery.International journal of molecular sciences · 2022Review
- Falls in people post-Guillain-Barré syndrome in the United Kingdom: A national cross-sectional survey of community based adults.Health & social care in the community · 2022Article
- Limb Remote Ischemic Conditioning Promotes Neurogenesis after Cerebral Ischemia by Modulating miR-449b/Notch1 Pathway in Mice.Biomolecules · 2022Article
- Mapping cis-regulatory elements in human neurons links psychiatric disease heritability and activity-regulated transcriptional programs.Cell reports · 2022Article
- Development and feasibility testing of action observation training videos in acute stroke survivors: Preliminary findings.F1000Research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Ischemic stroke is a devastating brain injury and an important cause of neurologic disability worldwide and across the lifespan. Despite the physical, social, and economic burdens of this disease there is only a single approved medicine for the treatment of acute stroke, and its use is unfortunately limited to the small fraction of patients presenting within the narrow therapeutic window. Following stroke, there is a period of plasticity involving cell genesis, axon growth, and synaptic modulation that is essential to spontaneous recovery. Treatments focusing on neuroprotection and enhancing recovery have been the focus of intense preclinical studies, but translation of these treatments into clinical use has been disappointing thus far. The important role of epigenetic mechanisms in disease states is becoming increasingly apparent, including in ischemic stroke. These regulators of gene expression are poised to be critical mediators of recovery following stroke. In this review we discuss evidence for the role of epigenetics in neuroplasticity and the implications for stroke recovery.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.