Evidence map›Paper›PMID 25263578›Full record

ReviewFEMS yeast research2014

Role of asymmetric cell division in lifespan control in Saccharomyces cerevisiae.

Ryo Higuchi-Sanabria, Wolfgang M A Pernice, Jason D Vevea, Dana M Alessi Wolken, Istvan R Boldogh, Liza A Pon

Open access · bronzeAbstract readReview
In one paragraph

Review in FEMS yeast research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 74 citations in OpenAlex.

  1. Alterations of actin in aging.Journal of cell science · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Cell membrane asymmetries and cellular aging.The Biochemical journal · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Cellular senescence, rejuvenation and potential immortality.Proceedings. Biological sciences · 2022
    Review
  14. Moonlighting at the Poles: Non-Canonical Functions of Centrosomes.Frontiers in cell and developmental biology · 2022
    Review
  15. Regulation of sphingolipid synthesis by the G1/S transcription factor Swi4.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2021
    Article
  16. Article
  17. Review
  18. Article
  19. Extracellular Vesicles and the Propagation of Yeast Prions.Current topics in microbiology and immunology · 2021
    Article
  20. Septins in Stem Cells.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ryo Higuchi-SanabriaDepartment of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Wolfgang M A Pernice
Jason D Vevea
Dana M Alessi Wolken
Istvan R Boldogh
Liza A Pon
Columbia University · US

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
NUTRITIONT32DK007647 · NIDDK · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anthony W Ferrante, Lori M Zeltser · 1990 to 2026
$7.4M
MITOCHONDRIAL MOTILITY AND INHERITANCER01GM045735 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI PON, LIZA A · 1993 to 2016
$4.2M
CLINICAL AND TRANSLATIONAL SCIENCE AWARDTL1RR024158 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$1.6M
Mitochondrial-cytoskeletal interactions and agingR01GM096445 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PON, LIZA A · 2011 to 2014
$1.3M
MULTIPHOTON CONFOCAL MICROSCOPES10RR025686 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PON, LIZA A · 2010 to 2010
$499k
Howard Hughes Medical Institute 56006760NCI NIH HHS P30 CA013696NCRR NIH HHS 2 TL1 RR 24158-6NCRR NIH HHS S10 RR025686NCRR NIH HHS TL1 RR024158NIDDK NIH HHS 5 T32 DK7647NIDDK NIH HHS T32 DK007647NIGMS NIH HHS GM45735NIGMS NIH HHS GM45735S1NIGMS NIH HHS R01 GM045735NIGMS NIH HHS R01 GM096445
6 · The paper itself

Abstract

Aging determinants are asymmetrically distributed during cell division in S. cerevisiae, which leads to production of an immaculate, age-free daughter cell. During this process, damaged components are sequestered and retained in the mother cell, and higher functioning organelles and rejuvenating factors are transported to and/or enriched in the bud. Here, we will describe the key quality control mechanisms in budding yeast that contribute to asymmetric cell division of aging determinants including mitochondria, endoplasmic reticulum (ER), vacuoles, extrachromosomal rDNA circles (ERCs), and protein aggregates.

Indexed as

Asymmetric Cell DivisionBiological TransportOrganellesSaccharomyces cerevisiaeasymmetric cell divisionlifespan controlmother-daughter age asymmetry

Identifiers

PMID25263578
PMCPMC4270926
OpenAlexW2114123456

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.