ArticleCell reports2014
Enteroendocrine cells support intestinal stem-cell-mediated homeostasis in Drosophila.
Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed, 157 citations in OpenAlex.
- Sex-biased expression of enteroendocrine cell-derived hormones contributes to higher fat storage ineLife · 2026Article
- Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in Drosophila.Nature communications · 2026Article
- Autophagy inhibition in intestinal stem cells favors enteroendocrine cell differentiation through Stat92E activity.Disease models & mechanisms · 2025Article
- Regulatory Mechanism of Intestinal Stem Cells Based on Hippo Pathway and Signaling Crosstalk in Chicken.International journal of molecular sciences · 2025Review
- Alternate Grainy head isoforms regulate Drosophila midgut intestinal stem cell differentiation.Cell death discovery · 2025Article
- Gut-Brain Dialogues in Fruit Fly (Current drug targets · 2025Review
- Drosophila Intestine as a Model to Study Tumors.Advances in experimental medicine and biology · 2025Review
- Article
- Enteroendocrine cells regulate intestinal homeostasis and epithelial function.Molecular and cellular endocrinology · 2024Review
- Gut-to-brain regulation ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Gut-to-brain regulation ofbioRxiv : the preprint server for biology · 2024Article
- Article
- Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion.Nature communications · 2024Article
- Eclosion muscles secrete ecdysteroids to initiate asymmetric intestinal stem cell division in Drosophila.Developmental cell · 2024Article
- Review
- Insights into midgut cell types and their crucial role in antiviral immunity in the lepidopteran modelFrontiers in immunology · 2024Review
- Disruptions in cell fate decisions and transformed enteroendocrine cells drive intestinal tumorigenesis in Drosophila.Cell reports · 2023Article
- Human intestinal organoids from Cronkhite-Canada syndrome patients reveal link between serotonin and proliferation.The Journal of clinical investigation · 2023Article
- Cholinergic neurons trigger epithelial CaNature · 2023Article
- Bioelectric regulation of intestinal stem cells.Trends in cell biology · 2023Review
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Intestinal stem cells in the adult Drosophila midgut are regulated by growth factors produced from the surrounding niche cells including enterocytes and visceral muscle. The role of the other major cell type, the secretory enteroendocrine cells, in regulating intestinal stem cells remains unclear. We show here that newly eclosed scute loss-of-function mutant flies are completely devoid of enteroendocrine cells. These enteroendocrine cell-less flies have normal ingestion and fecundity but shorter lifespan. Moreover, in these newly eclosed mutant flies, the diet-stimulated midgut growth that depends on the insulin-like peptide 3 expression in the surrounding muscle is defective. The depletion of Tachykinin-producing enteroendocrine cells or knockdown of Tachykinin leads to a similar although less severe phenotype. These results establish that enteroendocrine cells serve as an important link between diet and visceral muscle expression of an insulin-like growth factor to stimulate intestinal stem cell proliferation and tissue growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.