ArticleEnvironmental science and pollution research international2015
Perturbations in ROS-related processes of the fish Gambusia holbrooki after acute and chronic exposures to the metals copper and cadmium.
Article in Environmental science and pollution research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 31 citations in OpenAlex.
- Acute toxicity of mercury in response to metallothionein expression and oxidative and cellular metabolic stress in Barbonymus gonionotus.Scientific reports · 2025Article
- Oxidative stress, gene expression and histopathology of cultured gilthead sea bream (Sparus aurata) naturally co-infected with Ergasilus sieboldi and Vibrio alginolyticus.BMC veterinary research · 2023Article
- Seasonal assessment of selected trace elements in grass carp (Ctenopharyngodon idella) blood and their effects on the biochemistry and oxidative stress markers.Environmental monitoring and assessment · 2023Article
- Evaluation of metal contamination effects in piranhas through biomonitoring and multi biomarkers approach.Heliyon · 2020Article
- Use of biochemical markers to quantify the toxicological effects of metals on the fish Sciades herzbergii: potential use to assess the environmental status of Amazon estuaries.Environmental science and pollution research international · 2020Article
- Behavioral and biochemical effects of the antifouler and antidandruff zinc pyrithione on the freshwater fish Gambusia holbrooki.Fish physiology and biochemistry · 2019Article
- Orexin-A Rescues Chronic Copper-Dependent Behavioral and HSP90 Transcriptional Alterations in the Ornate Wrasse Brain.Neurotoxicity research · 2017Article
- Multibiomarker toxicity characterization of uranium mine drainages to the fish Carassius auratus.Environmental science and pollution research international · 2016Article
- Contaminant-induced oxidative stress in fish: a mechanistic approach.Fish physiology and biochemistry · 2016Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metallic contamination is a widespread phenomena, particularly in areas impacted by human activities, and has become a relevant environmental concern. However, the toxicity of metals on fish requires full characterization in terms of short- and long-term effects. Thus, the purpose of this study was to determine the acute and chronic oxidative stress response in liver and gills of Gambusia holbrooki exposed to copper and cadmium. To assess the effects of these two metals, we adopted a strategy of analyzing the pollution effects caused by salts of the two metallic elements, and we quantified the oxidative stress biomarkers catalase, glutathione reductase, glutathione-S-transferases, and lipid peroxidation after exposure (4 and 28 days) to ecologically relevant concentrations, thus simulating actual conditions of exposure in the wild. Our results showed that copper elicited strong effects in all tested biomarkers for both acute and chronic challenges. Cadmium caused a similar response and was shown to cause significant changes particularly in catalase and glutathione-S-transferases activities. These findings evidence that ecologically relevant concentrations of common anthropogenic contaminants are causative agents of serious imbalances (namely oxidative stress) that are likely to trigger life-threatening events.
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