Evidence map›Paper›PMID 2526337›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America1989

Mouse Mos protooncogene product is present and functions during oogenesis.

R S Paules, R Buccione, R C Moschel, G F Vande Woude, J J Eppig

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 171 citations in OpenAlex.

  1. Role of zinc in female reproduction.Biology of reproduction · 2021
    Review
  2. Article
  3. Article
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  7. Article
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  10. Okadaic acid, an inhibitor of protein phosphatase 1 and 2A, induces premature separation of sister chromatids during meiosis I and aneuploidy in mouse oocytes in vitro.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2003
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Inhibition of v-Mos kinase activity by protein kinase A.Molecular and cellular biology · 1996
    Article
  18. Article
  19. Review
  20. Mos overexpression in Swiss 3T3 cells induces meiotic-like alterations of the mitotic spindle.Proceedings of the National Academy of Sciences of the United States of America · 1995
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

R S PaulesBRI-Basic Research Program, National Cancer Institute-Frederick Cancer Research Facility, MD 21701.
R Buccione
R C Moschel
G F Vande Woude
J J Eppig
Frederick National Laboratory for Cancer Research · USNational Cancer Institute · US

Funding

PROVIDE BASIC CANCER RESEARCHN01CO074101 · CO · ADVANCED BIOSCIENCE LABORATORIES, INC. · PI VANDE WOUDE, GEORGE F · 1987 to 1994
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REGULATION OF MAMMALIAN OOCYTE DEVELOPMENTR01HD020575 · NICHD · JACKSON LABORATORY · PI EPPIG, JOHN J · 1985 to 1993
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NCI NIH HHS N01-CO-74101NICHD NIH HHS HD20575
6 · The paper itself

Abstract

We have identified the mouse Mos-encoded protein product, p39mos, in maturing mouse oocytes and have shown that it is indistinguishable from the product expressed in Mos-transformed NIH 3T3 cells. p39mos is detected in oocytes arrested in the first meiotic prophase, during germinal-vesicle breakdown, metaphase I, anaphase I, and in ovulated eggs. We show that microinjection of three different Mos antisense (but not sense) oligodeoxyribonucleotides into germinal vesicle-stage oocytes prevents first polar-body emission and therefore interrupted the normal progression of meiosis. These results show that in mouse oocytes, as in the amphibian Xenopus [Sagata, N., Oskarsson, M., Copeland, T., Brumbaugh, J. & Vande Woude, G.F. (1988) Nature (London) 335, 519-525], the product of Mos is necessary for normal meiotic maturation.

Indexed as

OogenesisProto-OncogenesAnimalsBase SequenceCells, CulturedFemaleMeiosisMiceMolecular Sequence DataOligonucleotide ProbesOocytesProto-Oncogene ProteinsProto-Oncogene Proteins c-mosXenopusOligonucleotide ProbesProto-Oncogene ProteinsProto-Oncogene Proteins c-mos

Identifiers

PMID2526337
PMCPMC297629
OpenAlexW2023584657

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.