ArticleBMC genomics2014
Comparative genome analysis of entomopathogenic fungi reveals a complex set of secreted proteins.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
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- Endophytic entomopathogenic fungi: The next frontier in mycological biocontrol.World journal of microbiology & biotechnology · 2026Review
- Species-Discriminating Diagnostic PCR, Ribosomal Intergenic Spacer-Based Single-Marker Taxonomy and Cryptic Descriptions of the Fungal EntomopathogensJournal of fungi (Basel, Switzerland) · 2026Article
- The chitinolytic enzymes from the entomopathogenic fungusFrontiers in fungal biology · 2026Review
- Comparative transcriptome analysis to unveil genes affecting the host cuticle destruction in Metarhizium rileyi.Current genetics · 2023Article
- Trichoderma-Derived Pentapeptides from the Infected Nest Mycobiome of the Subterranean Termite Coptotermes testaceus.Chembiochem : a European journal of chemical biology · 2022Article
- TwoJournal of fungi (Basel, Switzerland) · 2022Article
- Genomic Sequence and Transcriptome Analysis of the Medicinal Fungus Keithomyces neogunnii.Genome biology and evolution · 2022Article
- Genomic signatures and insights into host niche adaptation of the entomopathogenic fungus Metarhizium humberi.G3 (Bethesda, Md.) · 2022Article
- Comparative genome analyses suggest a hemibiotrophic lifestyle and virulence differences for the beech bark disease fungal pathogens Neonectria faginata and Neonectria coccinea.G3 (Bethesda, Md.) · 2021Article
- Article
- An Overview of Genomics, Phylogenomics and Proteomics Approaches in Ascomycota.Life (Basel, Switzerland) · 2020Review
- Genome-wide DNA methylation analysis of Metarhizium anisopliae during tick mimicked infection condition.BMC genomics · 2019Article
- Molecular evolution of Pr1 proteases depicts ongoing diversification in Metarhizium spp.Molecular genetics and genomics : MGG · 2019Article
- Secretomic analysis of Beauveria bassiana related to cattle tick, Rhipicephalus microplus, infection.Folia microbiologica · 2019Article
- Reprogramming the virulence: Insect defense molecules navigating the epigenetic landscape of Metarhizium robertsii.Virulence · 2018Article
- The entomopathogenic fungus Metarhizium robertsii communicates with the insect host Galleria mellonella during infection.Virulence · 2018Article
- Mode of Infection of Metarhizium spp. Fungus and Their Potential as Biological Control Agents.Journal of fungi (Basel, Switzerland) · 2017Review
- Article
- The Insect Pathogens.Microbiology spectrum · 2017Review
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Authors and funding
22 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetarhizium anisopliae is an entomopathogenic fungus used in the biological control of some agricultural insect pests, and efforts are underway to use this fungus in the control of insect-borne human diseases. A large repertoire of proteins must be secreted by M. anisopliae to cope with the various available nutrients as this fungus switches through different lifestyles, i.e., from a saprophytic, to an infectious, to a plant endophytic stage. To further evaluate the predicted secretome of M. anisopliae, we employed genomic and transcriptomic analyses, coupled with phylogenomic analysis, focusing on the identification and characterization of secreted proteins.
resultsWe determined the M. anisopliae E6 genome sequence and compared this sequence to other entomopathogenic fungi genomes. A robust pipeline was generated to evaluate the predicted secretomes of M. anisopliae and 15 other filamentous fungi, leading to the identification of a core of secreted proteins. Transcriptomic analysis using the tick Rhipicephalus microplus cuticle as an infection model during two periods of infection (48 and 144 h) allowed the identification of several differentially expressed genes. This analysis concluded that a large proportion of the predicted secretome coding genes contained altered transcript levels in the conditions analyzed in this study. In addition, some specific secreted proteins from Metarhizium have an evolutionary history similar to orthologs found in Beauveria/Cordyceps. This similarity suggests that a set of secreted proteins has evolved to participate in entomopathogenicity.
conclusionsThe data presented represents an important step to the characterization of the role of secreted proteins in the virulence and pathogenicity of M. anisopliae.
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