ArticleActa pharmacologica Sinica2014
Dietary high-fat lard intake induces thyroid dysfunction and abnormal morphology in rats.
Article in Acta pharmacologica Sinica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- A systematic review and meta-analysis investigating the relationship between metabolic syndrome and the incidence of thyroid diseases.Endocrine · 2024Pooled it
- Metabolic syndrome and risk of subclinical hypothyroidism: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Effect of long-term use of very low-carbohydrate Ketogenic diet on the thyroid gland and adipose tissue of adult male albino rats (biochemical and histological study).Journal of molecular histology · 2026Article
- Overnutrition in mice impairs thyroid hormone biosynthesis and utilization, causing hypothyroidism, despite remarkable thyroidal adaptations.The Journal of clinical investigation · 2026Article
- Clinical and metabolic links between hypothyroidism and metabolic syndrome: a review.Frontiers in endocrinology · 2026Review
- Systematic genetic investigation on relative macronutrient intake, circulating metabolic biomarkers and the risk of autoimmune diseases.NPJ science of food · 2025Article
- Muscle Strength, Lipid Metabolism and Hepatic Steatosis Are Improved with Ursolic Acid Treatment in High-Fat Diet-Induced Obese Mice.Nutrients · 2025Article
- Relationship between plasma atherogenic index and thyroid function: evidence from NHANES 2007-2012.Scientific reports · 2025Article
- The health status and the prevalence of metabolic disorders of adult endemic cretinism-An epidemiological study in China.Lipids in health and disease · 2025Article
- Prevalence and associated factors of obesity in patients with major depressive disorder at different ages of onset.European archives of psychiatry and clinical neuroscience · 2025Article
- Thyroid-Stimulating Hormone: An Important Target for the Prevention of Nonalcoholic Fatty Liver Disease.Physiological research · 2025Review
- Effect of a Low-Molecular-Weight Allosteric Agonist of the Thyroid-Stimulating Hormone Receptor on Basal and Thyroliberin-Stimulated Activity of Thyroid System in Diabetic Rats.International journal of molecular sciences · 2025Article
- Serum Lipidome and Metabolome Alterations in Obese Patients Undergoing Targeted Diet and Exercise Interventions: A Marker of Thyroid Function Recovery?International journal of endocrinology · 2025Article
- The effects of obesity on thyroid function in a metabolically healthy high-fat, high-carbohydrate diet-induced obese rat model.Frontiers in endocrinology · 2025Article
- Postprandial triglyceride levels affecting postprandial thyroid stimulating hormone levels may be responsible for the increased postprandial thyroid stimulating hormone levels in people with reduced lipid tolerance.Frontiers in endocrinology · 2025Article
- Bridging Microbiomes: Exploring Oral and Gut Microbiomes in Autoimmune Thyroid Diseases- New Insights and Therapeutic Frontiers.Gut microbes reports · 2025Review
- Obesity and Obesity-Related Thyroid Dysfunction: Any Potential Role for the Very Low-Calorie Ketogenic Diet (VLCKD)?Current nutrition reports · 2024Review
- Review
- Dietary Patterns and Hypothyroidism in U.S. Adult Population.Nutrients · 2024Article
- Analysis of the correlation between Hashimoto's thyroiditis and food intolerance.Frontiers in nutrition · 2024Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimExcess dietary fat intake can induce lipotoxicity in non-adipose tissues. The aim of this study was to observe the effects of dietary high-fat lard intake on thyroid in rats.
methodsMale Sprague-Dawley rats were fed a high-fat lard diet for 24 weeks, and then the rats were fed a normal control diet (acute dietary modification) or the high-fat lard diet for another 6 weeks. The serum lipid profile, total thyroxine (TT4), free thyroxine (FT4) and thyrotropin (TSH) levels were determined at the 12, 18, 24 and 30 weeks. High-frequency ultrasound scanning of the thyroid glands was performed at the 24 or 30 weeks. After the rats were sacrificed, the thyroid glands were collected for histological and immunohistochemical analyses.
resultsThe high-fat lard diet significantly increased triglyceride levels in both the serum and thyroid, and decreased serum TT4 and FT4 levels in parallel with elevated serum TSH levels. Ultrasonic imaging revealed enlarged thyroid glands with lowered echotexture and relatively heterogeneous features in the high-fat lard fed rats. The thyroid glands from the high-fat lard fed rats exhibited enlarged follicle cavities and flattened follicular epithelial cells under light microscopy, and dilated endoplasmic reticulum cisternae, twisted nuclei, fewer microvilli and secretory vesicles under transmission electron microscopy. Furthermore, the thyroid glands from the high-fat lard fed rats showed markedly low levels of thyroid hormone synthesis-related proteins TTF-1 and NIS. Acute dietary modification by withdrawal of the high-fat lard diet for 6 weeks failed to ameliorate the high-fat lard diet-induced thyroid changes.
conclusionDietary high-fat lard intake induces significant thyroid dysfunction and abnormal morphology in rats, which can not be corrected by short-term dietary modification.
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