ArticleJournal of psychiatric research2014
Amygdala enlargement in unaffected offspring of bipolar parents.
Article in Journal of psychiatric research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder.Biological psychiatry · 2019Pooled it
- Mapping Structural Neuroimaging Trajectories in Bipolar Disorder: Neurobiological and Clinical Implications.Biological psychiatry · 2025Review
- Specificity of associations between parental psychopathology and offspring brain structure.Psychiatry research. Neuroimaging · 2023Article
- Functional Alterations in Patients with Bipolar Disorder and Their Unaffected First-Degree Relatives: Insight from Genetic, Epidemiological, and Neuroimaging Data.Neuropsychiatric disease and treatment · 2023Review
- Neuroanatomic and Functional Neuroimaging Findings.Current topics in behavioral neurosciences · 2021Article
- Altered directed functional connectivity of the right amygdala in depression: high-density EEG study.Scientific reports · 2020Article
- Association between IFN-γ +874 T/A (Rs2430561) Polymorphisms and Bipolar 1 Disorder: A Study in an Ethnic Iranian Population.Reports of biochemistry & molecular biology · 2019Article
- A Multilevel Functional Study of aThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The Lausanne-Geneva cohort study of offspring of parents with mood disorders: methodology, findings, current sample characteristics, and perspectives.Social psychiatry and psychiatric epidemiology · 2017Article
- White matter volumes in youth offspring of bipolar parents.Journal of affective disorders · 2017Article
- Gray matter volumes in symptomatic and asymptomatic offspring of parents diagnosed with bipolar disorder.European child & adolescent psychiatry · 2016Article
- Rostral Middle Frontal Volumetric Differences in Bipolar Offspring versus Community Controls Offspring.International journal of psychological researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundBipolar disorder (BD) is a devastating disorder with a strong genetic component. While the frontolimbic profile of individuals suffering from BD is relatively well-established, there is still disagreement over the neuroanatomical features of unaffected BD offspring. MATERIAL AND
methodsBrain volumetric measures were obtained for 82 children and adolescents including 18 unaffected BD offspring (10.50 ± 3.37 years), 19 BD offspring suffering from psychiatric disorders (12.87 ± 3.28 years) and 45 healthy controls (HC-10.50 ± 3.37 years). Clinical diagnoses were established according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. Cortical reconstruction and volumetric segmentation were performed with the Freesurfer image analysis suite. Profile analyses compared frontolimbic volumes across groups. Age, gender, testing site, ethnicity and intracranial volume were entered as covariates.
resultsThe right amygdala was significantly larger in unaffected BD offspring compared to BD offspring with psychiatric disorders and HC. Volumes of striatal, hippocampal, cingulate, and temporal regions were comparable across groups. DISCUSSION: The size of the amygdala may be a marker of disease susceptibility in offspring of BD parents. Longitudinal studies are needed to examine rates of conversion to BD as related to specific pre-morbid brain abnormalities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.