Evidence map›Paper›PMID 25263276›Full record

ArticleJournal of psychiatric research2014

Association between mental disorders and subsequent adult onset asthma.

Jordi Alonso, Peter de Jonge, Carmen C W Lim, Sergio Aguilar-Gaxiola, Ronny Bruffaerts, Jose Miguel Caldas-de-Almeida, Zhaorui Liu, Siobhan O'Neill, Dan J Stein, Maria Carmen Viana and 15 more

Open access · greenAbstract read
In one paragraph

Article in Journal of psychiatric research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Why Every Asthma Patient Tells a Different Story.Journal of clinical medicine · 2025
    Article
  5. Article
  6. Observational
  7. Systemic Inflammation in Asthma: What Are the Risks and Impacts Outside the Airway?The journal of allergy and clinical immunology. In practice · 2024
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Brain-Airway Interactions in Asthma.Advances in experimental medicine and biology · 2023
    Article
  13. Article
  14. Article
  15. Change in Asthma Is Associated with Change in PTSD in World Trade Center Health Registrants, 2011 to 2016.International journal of environmental research and public health · 2022
    Article
  16. Review
  17. Article
  18. Article
  19. Finding commonalities in rare diseases through the undiagnosed diseases network.Journal of the American Medical Informatics Association : JAMIA · 2021
    Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 20 institutions in 19 countries.

Jordi AlonsoHealth Services Research Unit, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Pompeu Fabra University (UPF), Barcelona, Spain. Electronic address: jalonso@imim.es.
Peter de JongeInterdisciplinary Center Psychopathology and Emotion Regulation, University Medical Center, University of Groningen, Groningen, The Netherlands.
Carmen C W LimDepartment of Psychological Medicine, Otago University, Dunedin, New Zealand.
Sergio Aguilar-GaxiolaUniversity of California, Davis, Center for Reducing Health Disparities, School of Medicine, Sacramento, CA, USA.
Ronny BruffaertsUniversitair Psychiatrisch Centrum - Katholieke Universiteit Leuven (UPC - KUL), Leuven, Belgium.
Jose Miguel Caldas-de-AlmeidaChronic Diseases Research Center (CEDOC) and Department of Mental Health, Faculdade de Ciencias Medicas, Universidade Nova de Lisboa, Lisbon, Portugal.
Zhaorui LiuInstitute of Mental Health, Peking University, Beijing, PR China.
Siobhan O'NeillBamford Centre for Mental Health and Well-Being, University of Ulster, Derry, Northern Ireland, UK.
Dan J SteinUniversity of Cape Town, Department of Psychiatry & Mental Health, Groote Schuur Hospital, Cape Town, South Africa.
Maria Carmen VianaDepartment of Social Medicine, Federal University of Espírito Santo (UFES), Vitória, Brazil.
Ali Obaid Al-HamzawiAl-Qadisia University College of Medicine, Diwania, Iraq.
Matthias C AngermeyerCenter for Public Mental Health, Gosing am Wagram, Austria.
Guilherme BorgesDivision of Epidemiological and Psychosocial Research, National Institute of Psychiatry (Mexico) and Metropolitan Autonomous University, Mexico City, Mexico.
Marius CiutanNational School of Public Health and Professional Development, Bucharest, Romania.
Giovanni de GirolamoIRCCS Centro S. Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Fabian FiestasEvidence Generation for Public Health Research Unit, National Institute of Health, Lima, Peru.
Josep Maria HaroParc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, Spain; CIBER de Salud Mental (CIBERSAM), Spain; University of Barcelona, Barcelona, Spain.
Chiyi HuShenzhen Institute of Mental Health and Shenzhen Kangning Hospital, Guangdong Province, PR China.
Ronald C KesslerDepartment of Health Care Policy, Harvard Medical School, Boston, MA, USA.
Jean Pierre LépineHôpital Saint-Louis Lariboisière Fernand Widal, INSERM U 705, CNRS UMR 8206, Paris, France.
Daphna LevinsonMental Health Services, Ministry of Health, Jerusalem, Israel.
Yosikazu NakamuraDepartment of Public Health, Jichi Medical University, Yakushiji, Shimotsuke-shi, Tochigi-ken, Japan.
Jose Posada-VillaColegio Mayor de Cundinamarca University, CALLE 28 No. 5B-02, Bogota, DC, Colombia.
Bogdan J WojtyniakDepartment-Centre of Monitoring and Analyses of Population Health, National Institute of Public Health-National Institute of Hygiene, Warsaw, Poland.
Kate M ScottDepartment of Psychological Medicine, Otago University, Dunedin, New Zealand.
University of Otago · NZCentre National de la Recherche Scientifique · FRCentro San Giovanni di Dio Fatebenefratelli · ITHarvard University · USJichi Medical University · JPKU Leuven · BENarodowy Instytut Zdrowia Publicznego PZH – Państwowy Instytut Badawczy · PLNational Institute of Quality · PENational School of Public Health, Management and Professional Development · ROParc Sanitari Sant Joan de Déu · ESPeking University · CNShenzhen KangNing Hospital · CNUniversidad Autónoma Metropolitana · MXUniversidad Colegio Mayor de Cundinamarca · COUniversidade Federal do Espírito Santo · BRUniversidade Nova de Lisboa · PTUniversitat Pompeu Fabra · ESUniversity Medical Center Groningen · NLUniversity of Al-Qadisiyah · IQUniversity of California, Davis · US

Funding

EPIDEMIOLOGY-- NATIONAL COMORBIDITY SURVEY REPLICATIONU01MH060220 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI KESSLER, RONALD C · 1999 to 2010
$18.7M
Risk Factors for Psychopathology in the WHO WMH SurveysR01MH070884 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI KESSLER, RONALD C · 2005 to 2009
$6.0M
Social Role Disability and Mental-Physical Co-MorbidityR01MH069864 · NIMH · KAISER FOUNDATION HEALTH PLAN OF WASHINGTON · PI VON KORFF, MICHAEL R · 2004 to 2007
$2.2M
CROSS-NATIONAL STUDIES OF DRUG INVOLVEMENT: WMH2000R01DA016558 · NIDA · MICHIGAN STATE UNIVERSITY · PI ANTHONY, JAMES CHRISTOPHER · 2003 to 2008
$1.7M
Drug Dependence Epidemiology and EnviromicsK05DA015799 · NIDA · MICHIGAN STATE UNIVERSITY · PI ANTHONY, JAMES CHRISTOPHER · 2003 to 2015
$1.4M
World Mental Health Consortium Annual Meeting 2003-07R13MH066849 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HEERINGA, STEVEN G · 2003 to 2007
$735k
Lebanon-Epidemiology: The NCS Replication StudyR03TW006481 · FIC · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI KESSLER, RONALD C · 2004 to 2006
$142k
FIC NIH HHS R03 TW006481FIC NIH HHS R03-TW006481NIDA NIH HHS K05 DA015799NIDA NIH HHS R01 DA016558NIMH NIH HHS R01 MH069864NIMH NIH HHS R01-MH069864NIMH NIH HHS R01 MH070884NIMH NIH HHS R13 MH066849NIMH NIH HHS R13-MH066849NIMH NIH HHS U01 MH060220NIMH NIH HHS U01-MH60220
6 · The paper itself

Abstract

BACKGROUND AND

objectivesAssociations between asthma and anxiety and mood disorders are well established, but little is known about their temporal sequence. We examined associations between a wide range of DSM-IV mental disorders with adult onset of asthma and whether observed associations remain after mental comorbidity adjustments.

methodsDuring face-to-face household surveys in community-dwelling adults (n = 52,095) of 19 countries, the WHO Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Asthma was assessed by self-report of physician's diagnosis together with age of onset. Survival analyses estimated associations between first onset of mental disorders and subsequent adult onset asthma, without and with comorbidity adjustment.

results1860 adult onset (21 years+) asthma cases were identified, representing a total of 2,096,486 person-years of follow up. After adjustment for comorbid mental disorders several mental disorders were associated with subsequent adult asthma onset: bipolar (OR = 1.8; 95%CI 1.3-2.5), panic (OR = 1.4; 95%CI 1.0-2.0), generalized anxiety (OR = 1.3; 95%CI 1.1-1.7), specific phobia (OR = 1.3; 95%CI 1.1-1.6); post-traumatic stress (OR = 1.5; 95%CI 1.1-1.9); binge eating (OR = 1.8; 95%CI 1.2-2.9) and alcohol abuse (OR = 1.5; 95%CI 1.1-2.0). Mental comorbidity linearly increased the association with adult asthma. The association with subsequent asthma was stronger for mental disorders with an early onset (before age 21).

conclusionsA wide range of temporally prior mental disorders are significantly associated with subsequent onset of asthma in adulthood. The extent to which asthma can be avoided or improved among those with early mental disorders deserves study.

Indexed as

AdolescentAdultAgedAsthmaComorbidityCross-Cultural ComparisonFemaleGlobal HealthHumansInternational CooperationMaleMental DisordersMiddle AgedRetrospective StudiesYoung AdultAsthmaChronic diseaseComorbidityEpidemiologyMental disordersPopulation

Identifiers

PMID25263276
PMCPMC5120389
OpenAlexW2067232557

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.