Evidence map›Paper›PMID 25263226›Full record

ArticleReproductive toxicology (Elmsford, N.Y.)2014

Effects of early life exposure to methylmercury in Daphnia pulex on standard and reduced food ration.

Dzigbodi A Doke, Sherri L Hudson, John A Dawson, Julia M Gohlke

Abstract read
In one paragraph

Article in Reproductive toxicology (Elmsford, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The effect of a low iron diet and early life methylmercury exposure in Daphnia pulex.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dzigbodi A DokeDepartment of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.
Sherri L HudsonDepartment of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.
John A DawsonDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.
Julia M GohlkeDepartment of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA. Electronic address: jgohlke@uab.edu.

Funding

UAB Statistical Genetics Post-Doctoral Training ProgramT32HL072757 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TIWARI, HEMANT K. · 2003 to 2016
$3.8M
NHLBI NIH HHS T32 HL072757
6 · The paper itself

Abstract

As a well-known eco-toxicological model organism, Daphnia pulex may also offer advantages in human health research for assessing long-term effects of early life exposures to coupled stressors. Here, we examine consequences of early life exposure to methylmercury (MeHg) under standard and reduced food ration. We exposed Daphnia for 24h in early life to varying concentrations of methylmercury(II) chloride (0, 200, 400, 800 and 1600ng/L) and thereafter kept Daphnia on either a standard or a reduced food ration. The data suggests an additive effect of MeHg concentration and food ration on decreasing lifespan, although MeHg concentration does not affect survival linearly. Food ration and MeHg concentration were predictive of reduced reproduction, and there is some evidence of an interaction (p=0.048). Multi-stressor work in alternative model systems may be useful for prioritizing research, taking into account potential antagonistic, additive or synergistic effects that nutritional status may have on chemical toxicity.

Indexed as

AnimalsDaphniaDose-Response Relationship, DrugEnvironmental ExposureFood DeprivationMethylmercury CompoundsReproductionmethylmercuric chlorideMethylmercury CompoundsDaphnia pulexEarly lifeMethylmercuryNutritionReproductionSurvivorship

Identifiers

PMID25263226
PMCPMC4804713

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.