ArticleActa biomaterialia2015
Engineering a vascularized collagen-β-tricalcium phosphate graft using an electrochemical approach.
Article in Acta biomaterialia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Translating musculoskeletal bioengineering into tissue regeneration therapies.Science translational medicine · 2022Review
- Effect of Angiogenesis in Bone Tissue Engineering.Annals of biomedical engineering · 2022Review
- Biodegradable Inks in Indirect Three-Dimensional Bioprinting for Tissue Vascularization.Frontiers in bioengineering and biotechnology · 2022Review
- Multiple channels with interconnected pores in a bioceramic scaffold promote bone tissue formation.Scientific reports · 2021Article
- Blood Flow Within Bioengineered 3D Printed Vascular Constructs Using the Porcine Model.Frontiers in cardiovascular medicine · 2021Article
- Vascularized Bone-Mimetic Hydrogel Constructs by 3D Bioprinting to Promote Osteogenesis and Angiogenesis.International journal of molecular sciences · 2019Article
- Injectable shear-thinning hydrogels for delivering osteogenic and angiogenic cells and growth factors.Biomaterials science · 2018Article
- Biomaterials for Craniofacial Bone Regeneration.Dental clinics of North America · 2017Review
- The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering.Journal of visualized experiments : JoVE · 2016Article
- The application of cell sheet engineering in the vascularization of tissue regeneration.Regenerative medicine · 2016Review
- Plasmonic Surfaces for Cell Growth and Retrieval Triggered by Near-Infrared Light.Angewandte Chemie (International ed. in English) · 2016Article
- In Vivo Anastomosis and Perfusion of a Three-Dimensionally-Printed Construct Containing Microchannel Networks.Tissue engineering. Part C, Methods · 2016Article
- Bone Tissue Engineering with Multilayered Scaffolds-Part I: An Approach for Vascularizing Engineered Constructs In Vivo.Tissue engineering. Part A · 2015Article
- Vascularization in bone tissue engineering constructs.Annals of biomedical engineering · 2015Review
- Geometrical versus Random β-TCP Scaffolds: Exploring the Effects on Schwann Cell Growth and Behavior.PloS one · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Vascularization of three-dimensional large synthetic grafts for tissue regeneration remains a significant challenge. Here we demonstrate an electrochemical approach, named the cell electrochemical detachment (CED) technique, to form an integral endothelium and use it to prevascularize a collagen-β-tricalcium phosphate (β-TCP) graft. The CED technique electrochemically detached an integral endothelium from a gold-coated glass rod to a collagen-infiltrated, channeled, macroporous β-TCP scaffold, forming an endothelium-lined microchannel containing graft upon removal of the rod. The in vitro results from static and perfusion culture showed that the endothelium robustly emanated microvascular sprouting and prevascularized the entire collagen/β-TCP integrated graft. The in vivo subcutaneous implantation studies showed that the prevascularized collagen/β-TCP grafts established blood flow originating from the endothelium-lined microchannel within a week, and the blood flow covered more areas in the graft over time. In addition, many blood vessels invaded the prevascularized collagen/β-TCP graft and the in vitro preformed microvascular networks anastomosed with the host vasculature, while collagen alone without the support of rigid ceramic scaffold showed less blood vessel invasion and anastomosis. These results suggest a promising strategy for effectively vascularizing large tissue-engineered grafts by integrating multiple hydrogel-based CED-engineered endothelium-lined microchannels into a rigid channeled macroporous scaffold.
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