ArticleArchives of gerontology and geriatrics
The association between selenium and lipid levels: a longitudinal study in rural elderly Chinese.
Article in Archives of gerontology and geriatrics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Essential Trace Elements in Patients with Dyslipidemia: A Meta-analysis.Current medicinal chemistry · 2024Pooled it
- Selenium-enrichedFrontiers in fungal biology · 2026Article
- Investigating the Interplay of Toxic Metals and Essential Elements in Cardiovascular Disease.Journal of xenobiotics · 2025Article
- Metal mixture exposures and serum lipid levels in childhood: the Rhea mother-child cohort in Greece.Journal of exposure science & environmental epidemiology · 2024Article
- A cross-sectional analysis of the PURE study on minerals intake among Malaysian adult population with hypertension.Scientific reports · 2024Article
- How Do Minerals, Vitamins, and Intestinal Microbiota Affect the Development and Progression of Heart Disease in Adult and Pediatric Patients?Nutrients · 2023Review
- Association between Serum Selenium Levels and Lipids among People with and without Diabetes.Nutrients · 2023Article
- Role of selenium in type 2 diabetes, insulin resistance and insulin secretion.World journal of diabetes · 2023Review
- Beneficial effects of Se/Zn co-supplementation on body weight and adipose tissue inflammation in high-fat diet-induced obese rats.Food science & nutrition · 2021Article
- Article
- Selenium, copper, zinc and hypertension: an analysis of the National Health and Nutrition Examination Survey (2011-2016).BMC cardiovascular disorders · 2020Article
- Role of glutathione peroxidase 1 in glucose and lipid metabolism-related diseases.Free radical biology & medicine · 2018Review
- Effects of oral selenium and magnesium co-supplementation on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in rats fed a high-fat diet.Lipids in health and disease · 2018Article
- Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveA protective effect of selenium on lipid levels has been reported in populations with relatively low selenium status. However, recent studies found that high selenium exposure may lead to adverse cardiometabolic effects, particularly in selenium-replete populations. We examined the associations of selenium status with changes in lipid levels in a 7-year follow up of an elderly Chinese cohort including participants from selenium-deplete areas.
methodsStudy population consisted of 140 elderly Chinese aged 65 or older with nail selenium levels measured at baseline (2003-2005). Lipid concentrations were measured in fasting blood samples collected at baseline and the 7-year follow-up (2010-2012). Analysis of covariance (ANCOVA) models was used to determine the association between baseline selenium status and changes in lipid levels from baseline to follow-up adjusting for other covariates.
resultsMean (±standard deviation) baseline selenium concentration was 0.41±0.2mg/kg. In prospective analysis, we found that individuals in the highest selenium quartile group showed 1.11 SD decrease on total-cholesterol (p<0.001), 0.41 SD increase on HDL-cholesterol (p<0.001) and 0.52 SD decrease on triglyceride after 7 years than those in the lowest selenium quartile group. The similar trends were seen with significant lipid changes in the 2nd and 3rd quartile groups.
conclusionSelenium has modest beneficial effects on blood lipid levels in a population with relatively low selenium status. Our result suggests adequate dietary selenium intake as a potential prevention strategy for lowering lipid levels in selenium deplete populations.
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