ArticleAutonomic neuroscience : basic & clinical2014
Medullary regulation of visceral sympathetic nerve discharge at peak hyperthermia in aged F344 rats.
Article in Autonomic neuroscience : basic & clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Kidney physiology and pathophysiology during heat stress and the modification by exercise, dehydration, heat acclimation and aging.Temperature (Austin, Tex.) · 2021Review
- Does acute heat stress differentially-modulate expression of ionotropic neurotransmitter receptors in the RVLM of young and aged F344 rats?Neuroscience letters · 2018Article
- Microarray analysis of aging-associated immune system alterations in the rostral ventrolateral medulla of F344 rats.Physiological genomics · 2017Article
- Does aging alter the molecular substrate of ionotropic neurotransmitter receptors in the rostral ventral lateral medulla? - A short communication.Experimental gerontology · 2017Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Heat stress provides a potent stimulus for the activation of visceral sympathetic nerve discharge (SND) in young but not aged rats. Central mechanisms mediating attenuated SND responses to heating in aged rats have not been investigated. Because the GABAergic system in the rostral ventral lateral medulla (RVLM) is tonically inhibitory to SND, it is plausible to hypothesize that the withdrawal of RVLM GABA tone as a strategy to activate renal SND to heating is not engaged to the same degree in aged compared with young rats. The effect of bilateral RVLM disinhibition produced by bicuculline (BIC, GABA(A) receptor antagonist, 100 pmol) microinjections on renal SND in anesthetized young (3-6 months old) and aged (22-24 months old) Fischer 344 rats was determined after core body temperature (Tc) had been increased to 41.5 °C. Renal SND at 41.5 °C was significantly increased from control levels in young but not aged rats, whereas RVLM BIC microinjections at 41.5 °C produced marked renal sympathoexcitation in both groups. RVLM BIC microinjections at 38 °C in young and aged rats increased renal SND to similar levels as produced by RVLM BIC microinjections at 41.5 °C. The enhanced heating-induced renal sympathoactivation in young compared with aged rats; coupled with marked RVLM BIC-induced SND excitation under hyperthermic and normothermic conditions in both young and aged rats, suggests age-dependent changes in the withdrawal of RVLM GABA tone as a strategy to activate renal SND in response to acute heating.
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Registered trials
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