ArticleCellular microbiology2015
Contact-induced apical asymmetry drives the thigmotropic responses of Candida albicans hyphae.
Article in Cellular microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed.
- GcrR in Streptococcus mutans Inhibits the Morphological Transition of Candida albicans Through Ras1-cAMP/PKA Pathway in the Cross-Kingdom Biofilms.Molecular oral microbiology · 2026Article
- Disruption of thePathogens (Basel, Switzerland) · 2026Article
- Differential Thigmotropic Capacities Among Fusarial Isolates:Journal of fungi (Basel, Switzerland) · 2026Article
- Snooping helices: The elastic path finding algorithm of growing hyphae.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Association of Helicobacter pylori with Candida albicans enhances fungal virulence and stress tolerance.Gut pathogens · 2026Article
- Synthetic Lethal Therapy Based on Dimorphism for Systemic Infection of Drug-Resistant Candida albicans.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Revisiting fungal polarized growth: from Spitzenkörper to crescent accumulation of secretory vesicles.iScience · 2025Article
- Proximity labeling identification of plasma membrane eisosome proteins in Candida albicans.Genetics · 2025Article
- Fabrication of Lab-on-a-Chip Devices to Study the Forces Imparted by Growing Phytophthora Hyphae.Methods in molecular biology (Clifton, N.J.) · 2025Article
- The Cwr1 protein kinase localizes to the plasma membrane and mediates resistance to cell wall stress inmSphere · 2024Article
- The pathobiology of human fungal infections.Nature reviews. Microbiology · 2024Review
- The progress and future of the treatment of Candida albicans infections based on nanotechnology.Journal of nanobiotechnology · 2024Review
- Re-routing MAP kinase signaling for penetration peg formation in predator yeasts.PLoS pathogens · 2024Article
- Hyphae of the fungus Aspergillus nidulans demonstrate chemotropism to nutrients and pH.PLoS biology · 2024Article
- Article
- Anti-Cariogenic Effects ofPharmaceutics · 2024Article
- Plant cell-like tip-growing polymer precipitate with structurally embedded multistimuli sensing ability.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cell wall dynamics stabilize tip growth in a filamentous fungus.PLoS biology · 2023Article
- Article
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Authors and funding
7 authors.
Funding
Abstract
Filamentous hyphae of the human pathogen, Candida albicans, invade mucosal layers and medical silicones. In vitro, hyphal tips reorient thigmotropically on contact with small obstacles. It is not known how surface topography is sensed but hyphae lacking the cortical marker, Rsr1/Bud1, are unresponsive. We show that, on surfaces, the morphology of hyphal tips and the position of internal polarity protein complexes are asymmetrically skewed towards the substratum and biased towards the softer of two surfaces. In nano-fabricated chambers, the Spitzenkörper (Spk) responded to touch by translocating across the apex towards the point of contact, where its stable maintenance correlated with contour-following growth. In the rsr1Δ mutant, the position of the Spk meandered and these responses were attenuated. Perpendicular collision caused lateral Spk oscillation within the tip until after establishment of a new growth axis, suggesting Spk position does not predict the direction of growth in C. albicans. Acute tip reorientation occurred only in cells where forward growth was countered by hyphal friction sufficient to generate a tip force of ∼ 8.7 μN (1.2 MPa), more than that required to penetrate host cell membranes. These findings suggest mechanisms through which the organization of hyphal tip growth in C. albicans facilitates the probing, penetration and invasion of host tissue.
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