ArticleNature neuroscience2014
A somatosensory circuit for cooling perception in mice.
Article in Nature neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 86 citations in OpenAlex.
- The neuronal circuits and cellular encoding of thermosensation.Nature reviews. Neuroscience · 2026Review
- Physiological functions and pharmacological targeting of transient receptor potential channels.Pharmacological reviews · 2025Review
- A dedicated skin-to-brain circuit for cool sensation in mice.Nature communications · 2025Article
- Touch inhibits cold: non-contact cooling suggests a thermotactile gating mechanism.Proceedings. Biological sciences · 2025Article
- Role of thermosensitive transient receptor potential (TRP) channels in thermal preference of male and female mice.Journal of thermal biology · 2024Article
- Specific and Nonuniform Brain States during Cold Perception in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The secondary somatosensory cortex gates mechanical and heat sensitivity.Nature communications · 2024Article
- Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception.Nature communications · 2024Article
- Sensory Processing of Cutaneous Temperature in the Peripheral and Central Nervous System.Advances in experimental medicine and biology · 2024Review
- Brain-wide connectivity map of mouse thermosensory cortices.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The brain's encoding of warm and cool.Nature · 2023Article
- Article
- Thermal illusions for thermal displays: a review.Frontiers in human neuroscience · 2023Review
- Thermosensory thalamus: parallel processing across model organisms.Frontiers in neuroscience · 2023Review
- Somatosensory cortical signature of facial nociception and vibrotactile touch-induced analgesia.Science advances · 2022Article
- How Temperature Influences Sleep.International journal of molecular sciences · 2022Review
- Itch perception is reflected by neuronal ignition in the primary somatosensory cortex.National science review · 2022Article
- Modulation of the thermosensory system by oxytocin.Frontiers in molecular neuroscience · 2022Review
- Multiplexed Representation of Itch and Mechanical and Thermal Sensation in the Primary Somatosensory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Cutaneous pain in disorders affecting peripheral nerves.Neuroscience letters · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The temperature of an object provides important somatosensory information for animals performing tactile tasks. Humans can perceive skin cooling of less than one degree, but the sensory afferents and central circuits that they engage to enable the perception of surface temperature are poorly understood. To address these questions, we examined the perception of glabrous skin cooling in mice. We found that mice were also capable of perceiving small amplitude skin cooling and that primary somatosensory (S1) cortical neurons were required for cooling perception. Moreover, the absence of the menthol-gated transient receptor potential melastatin 8 ion channel in sensory afferent fibers eliminated the ability to perceive cold and the corresponding activation of S1 neurons. Our results identify parts of a neural circuit underlying cold perception in mice and provide a new model system for the analysis of thermal processing and perception and multimodal integration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.