Evidence map›Paper›PMID 25262376›Full record

SynthesisCancer epidemiology2014

The association between smokeless tobacco use and pancreatic adenocarcinoma: a systematic review.

Matthew D Burkey, Shari Feirman, Han Wang, Samuel Ravi Choudhury, Surbhi Grover, Fabian M Johnston

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancer epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Smoking and Male Infertility: An Evidence-Based Review.The world journal of men's health · 2015
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matthew D BurkeyDivision of Child & Adolescent Psychiatry, Johns Hopkins University School of Medicine, 550N. Broadway, Ste. 206, Baltimore, MD 21205, United States. Electronic address: mburkey1@jhmi.edu.
Shari FeirmanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 600N. Wolfe St., Baltimore, MD 21287, United States. Electronic address: sfeirman@jhsph.edu.
Han WangJohns Hopkins Bloomberg School of Public Health, 600N. Wolfe St., Baltimore, MD 21287, United States. Electronic address: han.wingss@gmail.com.
Samuel Ravi ChoudhuryYong Loo Lin School of Medicine, National University of Singapore, 21 Lower Kent Ridge Rd, Singapore 119077, Singapore. Electronic address: pravidence@gmail.com.
Surbhi GroverDepartment of Radiation Oncology, University of Pennsylvania, 3400 Civic Boulevard, Philadelphia, PA 19104, United States. Electronic address: surbhi.grover@uphs.upenn.edu.
Fabian M JohnstonDivision of Surgical Oncology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, United States. Electronic address: fjohnston@mcw.edu.

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
Institute for Clinical and Translational ResearchKL2TR001077 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$9.2M
NCATS NIH HHS KL2 TR001077NCI NIH HHS P30 CA006973
6 · The paper itself

Abstract

backgroundSmokeless tobacco is a possible risk factor for developing pancreatic adenocarcinoma. This systematic review addressed the question: Is there an association between smokeless tobacco use and pancreatic adenocarcinoma diagnosis?

methodsFive electronic databases, grey literature, and citations of relevant articles were searched to identify studies. Six researchers double-reviewed records for inclusion in the review. The information extracted from these studies was selected using criteria outlined in the Newcastle-Ottawa Quality Assessment Scale for observational studies. A qualitative synthesis of included studies was performed.

resultsThe search of electronic databases resulted in a total of 1747 citations. Eleven studies met the inclusion criteria for this review, including three cohort studies, seven case control studies and one study that pooled data from multiple case-control studies. Studies were heterogeneous in their assessment of exposure intensity and ascertainment of outcomes. Quality of the studies varied. Existing investigations of the association of interest appear to exhibit several types of biases including selection bias, information bias and bias in the analysis.

conclusionThe association between smokeless tobacco use and pancreatic adenocarcinoma is inconclusive. More definitive conclusions regarding this relationship await the results of more methodologically rigorous epidemiologic studies.

Indexed as

AdenocarcinomaCohort StudiesHumansPancreatic NeoplasmsRisk FactorsTobacco, SmokelessPancreatic cancerPancreatic neoplasmsSmokeless tobaccoSystematic reviewTobacco products

Identifiers

PMID25262376
PMCPMC4659362

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.