ArticleJournal of mathematical biology2015
The importance of volume exclusion in modelling cellular migration.
Article in Journal of mathematical biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Random walk models in the life sciences: including births, deaths and local interactions.Journal of the Royal Society, Interface · 2025Review
- Quantifying tissue growth, shape and collision via continuum models and Bayesian inference.Journal of the Royal Society, Interface · 2023Article
- Simulation of receptor triggering by kinetic segregation shows role of oligomers and close contacts.Biophysical journal · 2022Article
- Influence of confinement on the spreading of bacterial populations.PLoS computational biology · 2022Article
- Disentangling cadherin-mediated cell-cell interactions in collective cancer cell migration.Biophysical journal · 2022Article
- Detection and characterization of chemotaxis without cell tracking.Journal of the Royal Society, Interface · 2021Article
- Comparative analysis of continuum angiogenesis models.Journal of mathematical biology · 2021Article
- Biologically-informed neural networks guide mechanistic modeling from sparse experimental data.PLoS computational biology · 2020Article
- The impact of exclusion processes on angiogenesis models.Journal of mathematical biology · 2018Article
- Multidisciplinary approaches to understanding collective cell migration in developmental biology.Open biology · 2016Review
- Article
- Spatial moment dynamics for collective cell movement incorporating a neighbour-dependent directional bias.Journal of the Royal Society, Interface · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The modelling of collective migration has traditionally been undertaken in a continuous framework, with little reference to the individual-level mechanisms that give rise to such a concerted movement. One factor whose importance is now coming to light is that the individuals themselves occupy space in the domain, thus obstructing others from moving past them (volume exclusion). In this work, we systematically derive continuous descriptions of cellular migration with volume exclusion for a wide range of individual-based mechanisms and in one, two and three dimensions. We also consider subpopulations of migrating individuals, which may have different characteristics, such as differing sizes and speeds of migration. We demonstrate that volume exclusion is of particular importance when biased movement is included, and thus conclude that volume exclusion may have its greatest effect when considering directed migratory mechanisms such as chemotaxis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.