ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2015
Regulation of chondrosarcoma invasion by MMP26.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Article
- A Genome-Wide Profiling of Glioma Patients with an IDH1 Mutation Using the Catalogue of Somatic Mutations in Cancer Database.Cancers · 2021Article
- The Silencing of SFRP2 Expression in ESCC Is Due to Methylation of the Gene Promoter.Technology in cancer research & treatment · 2019Article
- Chondrosarcoma: A Rare Misfortune in Aging Human Cartilage? The Role of Stem and Progenitor Cells in Proliferation, Malignant Degeneration and Therapeutic Resistance.International journal of molecular sciences · 2018Review
- MMP26: A potential biomarker for prostate cancer.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2017Article
- Role of Matrix Metalloproteinases in the Pathogenesis of Traumatic Brain Injury.Molecular neurobiology · 2016Review
- MiR-125b regulates endometrial receptivity by targeting MMP26 in women undergoing IVF-ET with elevated progesterone on HCG priming day.Scientific reports · 2016Article
- Enhanced Wnt signaling by methylation-mediated loss of SFRP2 promotes osteosarcoma cell invasion.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Methylation-mediated loss of SFRP2 enhances melanoma cell invasion via Wnt signaling.American journal of translational research · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular mechanism underlying metastasis of chondrosarcoma (CS) remains unclarified. Here, we show that matrix metalloproteinase-26 (MMP26) level is significantly higher in the resected CS than in the adjacent healthy chondral tissue from the patients. To examine the role of MMP26 in CS invasion, we used a human CS line SW1353 and we either overexpressed or inhibited MMP26 in these cells. We found that overexpression of MMP26 in SW1353 cells increased cell invasiveness, while inhibition of MMP26 decreased cell invasiveness. To define the signal transduction cascades downstream of MMP26 activation, we applied specific inhibitors for PI3K, ERK/MAPK, JNK, and Wnt signaling, respectively, to the MMP26-overexpressing SW1353 cells. We found that only inhibition of Wnt signaling by either metformin or IWP-2 significantly decreased the effect of MMP26 on cancer cell invasion, possibly through increasing β-catenin phosphorylation. Further, a strong correlation was detected between MMP26 levels and the ratio of phosphorylated/total β-catenin in CS from the patients. Taken together, our study highlights MMP26-regulated Wnt signaling as a novel therapeutic target for CS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.