ArticleAmerican heart journal2014
Prevalence of glucose abnormalities among patients presenting with an acute myocardial infarction.
Article in American heart journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Glycosylated hemoglobin levels and clinical outcomes in nondiabetic patients with coronary artery disease: A meta-analysis.Medicine · 2017Pooled it
- THE IMPACT OF CARDIOVASCULAR DRUGS ON GLYCEMIC CONTROL: A REVIEW.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2017Pooled it
- Does Diabetes Mellitus Increase the Short- and Long-Term Mortality in Patients With Critical Acute Myocardial Infarction? Results From American MIMIC-III and Chinese CIN Cohorts.Frontiers in endocrinology · 2021Trial
- Predictors of 12-Month MACE Among Diabetic, Prediabetic, and Normoglycemic Patients Undergoing Elective Percutaneous Coronary Intervention: 10 Years' Experience From Tehran Heart Center.Health science reports · 2026Article
- Impact of elevated glucose levels on cardiac function in STEMI patients: glucose delta as a prognostic biomarker.Diabetology & metabolic syndrome · 2025Article
- Glycemic Comparison Index (GCI): a retrospective analysis of its prognostic value in ICU patients with AMI and diabetes.BMC endocrine disorders · 2025Article
- Elevated triglyceride glucose index is associated with advanced cardiovascular kidney metabolic syndrome.Scientific reports · 2024Article
- Differential Proteomic Profiles of Coronary Serum Exosomes in Acute Myocardial Infarction Patients with or Without Diabetes Mellitus: ANGPTL6 Accelerates Regeneration of Endothelial Cells Treated with Rapamycin via MAPK Pathways.Cardiovascular drugs and therapy · 2024Article
- Cardiovascular-Kidney-Metabolic Syndrome Among Healthcare Workers in Chinese Tertiary Hospital.Risk management and healthcare policy · 2024Article
- Effect of diabetes mellitus on 3-year outcomes in patients with acute myocardial infarction with nonobstructive coronary arteries.Cardiology journal · 2024Article
- An exploratory human study investigating the influence of type 2 diabetes on macrophage phenotype after myocardial infarction.International journal of cardiology. Heart & vasculature · 2023Article
- Exploring new insights in coronary lesion assessment and treatment in patients with diabetes mellitus: the impact of optical coherence tomography.Cardiovascular diabetology · 2023Review
- Elevated circulating levels of gasdermin D are related to acute myocardial infarction and pyrogptosis.BMC cardiovascular disorders · 2022Observational
- Anti-embolism devices therapy to improve the ICU mortality rate of patients with acute myocardial infarction and type II diabetes mellitus.Frontiers in cardiovascular medicine · 2022Article
- Glucose-lowering therapy in patients undergoing percutaneous coronary intervention.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2021Review
- Impact of admission hyperglycemia on short and long-term prognosis in acute myocardial infarction: MINOCA versus MIOCA.Cardiovascular diabetology · 2021Observational
- Quality of Diabetes Care in the USA.Current cardiology reports · 2021Review
- Effects of stent generation on clinical outcomes after acute myocardial infarction compared between prediabetes and diabetes patients.Scientific reports · 2021Article
- Sex differences in long-term clinical outcomes of acute myocardial infarction according to the presence of diabetes mellitus.The Korean journal of internal medicine · 2021Article
- Observational
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7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundPatients with an acute myocardial infarction (AMI) who have glucose abnormalities are at increased risk for death and adverse ischemic outcomes. The contemporary prevalence of glucose abnormalities among AMI patients in the United States, as determined by hemoglobin A1c (HbA1c), is unknown.
methodsPatients hospitalized with AMI in a 24-site US AMI registry from 2005 to 2008 were examined for the presence of dysglycemia using HbA1c, which was analyzed at a core laboratory. Patients were categorized by American Diabetes Association guidelines as having diabetes (HbA1c ≥ 6.5%), prediabetes (HbA1c 5.7%-6.4%), or normoglycemia. Baseline demographic, clinical, and metabolic characteristics, as well as long-term all-cause mortality, were compared among groups.
resultsAmong 2,853 patients with AMI, 1,083 (38%) had diabetes, of which 196 (18%) were newly diagnosed. There were an additional 887 patients (31%) with prediabetes and 883 patients (31%) who had normal glucose metabolism. Patients with metabolic abnormalities were older, were more frequently female, and had higher prevalence of cardiac and noncardiac comorbidities, including multivessel disease and left ventricular systolic dysfunction. Patients with increasing metabolic abnormalities had higher mortality over the 3 years after the AMI (8.6% in those with normoglycemia, 10.6% in prediabetes, 11.3% in newly diagnosed diabetes, and 20.3% in known diabetes; log rank P < .001).
conclusionsIn a large US AMI registry, we found that nearly 7 in 10 patients had dysglycemia, with 38% having diabetes and an additional 31% with prediabetes based on HbA1c levels. Over half of the patients who did not have a known diagnosis of diabetes at the time of admission had either newly diagnosed diabetes or prediabetes. Progressively greater severity of dysglycemia was also associated with incremental increase in long-term mortality. These data highlight the AMI hospitalization as a key opportunity to screen for glucose abnormalities so that appropriate interventions and patient education efforts can be implemented prior to discharge.
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