ArticleEnvironmental research2014
Residential agricultural pesticide exposures and risk of selected congenital heart defects among offspring in the San Joaquin Valley of California.
Article in Environmental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.
- Effects of Neonicotinoid Pesticide Exposure on Human Health: A Systematic Review.Environmental health perspectives · 2017Pooled it
- Biomonitoring-informed neonicotinoid mixture exposure reveals modest cytotoxicity and cell-type-specific molecular responses in human cell lines.BMC pharmacology & toxicology · 2026Article
- Determinants of residential pesticide contamination in vineyard regions: a structural equation modeling approach.Journal of exposure science & environmental epidemiology · 2026Article
- Review
- Article
- Environmental pollution effect on honey bees and their derived products: a comprehensive analysis.Environmental science and pollution research international · 2025Review
- Review
- Human acute poisoning incidents associated with neonicotinoid pesticides in the U.S. Incident Data System (IDS) database from 2018-2022 - frequency and severity show public health risks, regulatory failures.Environmental health : a global access science source · 2024Article
- Article
- Aiming for a Better Tomorrow.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Maternal pesticide exposure and risk of birth defects: a population-based cross-sectional study in China.Frontiers in public health · 2024Article
- Radiation and temperature drive diurnal variation of aerobic methane emissions from Scots pine canopy.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Characterization of Environmental Levels of Pesticide Residues in Household Air and Dust Samples near a Bioenergy Plant Using Treated Seed as Feedstock.International journal of environmental research and public health · 2023Article
- Residential proximity to agricultural pesticide use and risk-taking behaviors in young adults from the CHAMACOS study.Environmental research · 2022Article
- Identification and Application of Two Promising Peptide Ligands for the Immunodetection of Imidacloprid Residue.Foods (Basel, Switzerland) · 2022Article
- Association between new onset type 1 diabetes and real-world antibiotics and neonicotinoids' exposure-related gut microbiota perturbation.World journal of pediatrics : WJP · 2022Article
- Impact of High-Throughput Model Parameterization and Data Uncertainty on Thyroid-Based Toxicological Estimates for Pesticide Chemicals.Environmental science & technology · 2022Article
- A narrative review of converging evidence addressing developmental toxicity of pyrethroid insecticides.Critical reviews in toxicology · 2022Review
- Concurrent urinary organophosphate metabolites and acetylcholinesterase activity in Ecuadorian adolescents.Environmental research · 2022Article
- Residential proximity to pesticide applications in Argentine Patagonia: impact on pregnancy and newborn parameters.Environmental science and pollution research international · 2021Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPesticide exposures are ubiquitous and of substantial public concern. We examined the potential association of congenital heart defects with residential proximity to commercial agricultural pesticide applications in the San Joaquin Valley, California.
methodsStudy subjects included 569 heart defect cases and 785 non-malformed controls born from 1997 to 2006 whose mothers participated in a population-based case-control study. Associations with any versus no exposure to physicochemical groups of pesticides and specific chemicals were assessed using logistic regression adjusted for relevant covariates, for 8 heart defect phenotypes that included ≥ 50 cases and pesticide exposures with ≥ 5 exposed cases and controls, which resulted in 235 comparisons.
results38% of cases and controls were classified as exposed to pesticides within a 500 m radius of mother's address during a 3-month periconceptional window. Adjusted odds ratios (AORs) with 95% CIs excluding 1.0 were observed for 18 comparisons; all were >1 and ranged from 1.9 to 7.1. They included tetralogy of Fallot (n=101 cases) and neonicotinoids; hypoplastic left heart syndrome (n=59) and strobins; coarctation of the aorta (n=74) and pyridazinones; pulmonary valve stenosis (n=53) and bipyridyliums and organophosphates; ventricular septal defects (n=93) and avermectins and pyrethroids; and atrial septal defects (n=132) and dichlorphenoxy acid or esters, organophosphates, organotins, and pyrethroids. No AORs met both of these criteria for d-transposition of the great arteries (n=58) or heterotaxia (n=53).
conclusionsMost pesticides were not associated with increased risk of specific heart defect phenotypes. For the few that were associated, results should be interpreted with caution until replicated in other study populations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.