ArticleEnvironmental research2014
Domestic airborne black carbon levels and 8-isoprostane in exhaled breath condensate among children in New York City.
Article in Environmental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 33 citations in OpenAlex.
- Reduction of household air pollution through clean fuel intervention and recovery of cellular immune balance.Environment international · 2023Article
- Traffic-related air pollution, biomarkers of metabolic dysfunction, oxidative stress, and CC16 in children.Journal of exposure science & environmental epidemiology · 2022Article
- The Correlation of PM2.5 Exposure with Acute Attack and Steroid Sensitivity in Asthma.BioMed research international · 2022Review
- Increased Incidence of Dysmenorrhea in Women Exposed to Higher Concentrations of NO, NOFrontiers in public health · 2021Article
- Chemical Characterization of Seasonal PMInternational journal of environmental research and public health · 2020Article
- Effects of PMSaudi journal of biological sciences · 2019Article
- Effects of Short-Term Exposure to Particulate Air Pollutants on the Inflammatory Response and Respiratory Symptoms: A Panel Study in Schoolchildren from Rural Areas of Japan.International journal of environmental research and public health · 2016Article
- Short-Term Exposure to Air Pollution and Biomarkers of Oxidative Stress: The Framingham Heart Study.Journal of the American Heart Association · 2016Article
- Exposure to Deepwater Horizon Crude Oil Burnoff Particulate Matter Induces Pulmonary Inflammation and Alters Adaptive Immune Response.Environmental science & technology · 2015Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundExposure to airborne black carbon (BC) has been associated with asthma development, respiratory symptoms and decrements in lung function. However, the mechanism through which BC may lead to respiratory symptoms has not been completely elucidated. Oxidative stress has been suggested as a potential mechanism through which BC might lead to adverse health outcomes. Exhaled breath condensate (EBC) allows for the non-invasive collection of airway lining fluid containing biomarkers of oxidative stress like 8-isoprostane, a stable by-product of lipid peroxidation. Therefore, we sought to characterize the association between domestic airborne BC concentrations and 8-isoprostane in EBC. MATERIALS AND
methodsSeven- and eight-year-old children participated in an asthma case-control study in New York City. During home visits, air samples and EBC were collected. Seven day averages of domestic levels of particulate matter <2.5μm (PM2.5), BC and environmental tobacco smoke (ETS) were measured. Urea and 8-isoprostane were measured by liquid chromatography tandem mass spectrometry (LC/MS/MS) in EBC.
resultsIn univariate models, PM2.5 and BC, but not ETS, were significantly associated with increases in 8-isoprostane in the EBC (β=0.006 and β=0.106 respectively, p<0.05 for both). These associations remained statistically significant for both PM2.5 and BC after adjustment for covariates. In a co-pollutant model including PM2.5, BC and ETS, only BC remained a statistically significant predictor of 8-isoprostane (p<0.05).
conclusionsOur findings suggest the BC fraction of PM might contain exposure relevant to increased oxidative stress in the airways.
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