Evidence map›Paper›PMID 25261932›Full record

SynthesisNature genetics2014

Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.

James R Cerhan, Sonja I Berndt, Joseph Vijai, Hervé Ghesquières, James McKay, Sophia S Wang, Zhaoming Wang, Meredith Yeager, Lucia Conde, Paul I W de Bakker and 112 more

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 6 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 6 syntheses or guidelines pooled it, 174 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Article
  9. Characterization of Genetic Etiologic Factors for Pediatric Acute Lymphoblastic Leukemia in Large Childhood Cancer Survivorship Cohorts.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Article
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

122 authors at 20 institutions in 17 countries.

James R CerhanDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Joseph VijaiDepartment of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.ORCID 000000027933151X
Hervé Ghesquières1] Department of Hematology, Centre Léon Bérard, Lyon, France. [2] Laboratoire de Biologie Moléculaire de la Cellule, UMR 5239, CNRS, Pierre-Benite, France.
James McKayGenetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer, Lyon, France.
Sophia S WangDepartment of Cancer Etiology, City of Hope Beckman Research Institute, Duarte, California, USA.
Zhaoming WangCancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland, USA.
Meredith YeagerCancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland, USA.
Lucia Conde1] Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, Alabama, USA. [2] Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, California, USA.
Paul I W de Bakker1] Department of Medical Genetics and of Epidemiology, University Medical Center Utrecht, Utrecht, the Netherlands. [2] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID 0000000177357858
Alexandra NietersCenter for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany.
David CoxLyon, France.
Laurie BurdettCancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland, USA.
Alain Monnereau1] Environmental Epidemiology of Cancer Group, INSERM, Centre for Research in Epidemiology and Population Health (CESP), Villejuif, France. [2] UMRS 1018, Université Paris Sud, Villejuif, France. [3] Registre des Hémopathies Malignes de la Gironde, Institut Bergonié, Bordeaux, France.
Christopher R FlowersWinship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.
Anneclaire J De Roos1] Department of Environmental and Occupational Health, Drexel University School of Public Health, Philadelphia, Pennsylvania, USA. [2] Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Angela R Brooks-Wilson1] Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada. [2] Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Gianluca Severi1] Human Genetics Foundation, Turin, Italy. [2] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia. [3] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Carlton, Victoria, Australia.
Mads Melbye1] Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark. [2] Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Jian GuDepartment of Epidemiology, MD Anderson Cancer Center, Houston, Texas, USA.
Rebecca D JacksonDivision of Endocrinology, Diabetes and Metabolism, Ohio State University, Columbus, Ohio, USA.
Eleanor KaneDepartment of Health Sciences, University of York, York, UK.
Lauren R TerasEpidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.
Mark P PurdueDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Claire M VajdicPrince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000000236128298
John J Spinelli1] Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada. [2] School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
Graham G Giles1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia. [2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Carlton, Victoria, Australia.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Rachel S Kelly1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Medical Research Council (MRC)-Public Health England (PHE) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Mariagrazia ZuccaDepartment of Biomedical Science, University of Cagliari, Monserrato, Italy.
Kimberly A Bertrand1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Anne Zeleniuch-Jacquotte1] Department of Population Health, New York University School of Medicine, New York, New York, USA. [2] Cancer Institute, New York University School of Medicine, New York, New York, USA.
Charles LawrenceHealth Studies Sector, Westat, Rockville, Maryland, USA.
Amy HutchinsonCancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland, USA.
Degui ZhiDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Thomas M HabermannDepartment of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Brian K LinkDepartment of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
Anne J NovakDepartment of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Ahmet DoganDepartment of Laboratory Medicine and Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Yan W AsmannDivision of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, Florida, USA.
Mark LiebowDepartment of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Carrie A ThompsonDepartment of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Stephen M AnsellDepartment of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Thomas E WitzigDepartment of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
George J WeinerDepartment of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
Amelie S VeronLyon, France.
Diana ZelenikaCentre National de Génotypage, Evry, France.
Hervé TillyCentre Heni Becquerel, Rouen, France.
Corinne HaiounDepartment of Hematology, Centre Hospitalier Universitaire (CHU) Henri Mondor, Creteil, France.
Thierry Jo MolinaDepartment of Pathology, Necker Enfants Malades, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Henrik HjalgrimDepartment of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark.
Bengt Glimelius1] Department of Oncology and Pathology, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden. [2] Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden.
Hans-Olov Adami1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Paige M BracciDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Jacques Riby1] Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, Alabama, USA. [2] Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, California, USA.
Martyn T SmithDivision of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, California, USA.
Elizabeth A HollyDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Wendy Cozen1] Department of Preventive Medicine, University of Southern California Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Patricia HartgeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Lindsay M MortonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Richard K SeversonDepartment of Family Medicine and Public Health Sciences, Wayne State University, Detroit, Michigan, USA.
Lesley F TinkerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.ORCID 0000000324691929
Kari E North1] Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [2] Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Nikolaus BeckerDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Yolanda Benavente1] Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d'Oncologia, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. [2] Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
Paolo BoffettaTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Paul BrennanGroup of Genetic Epidemiology, Section of Genetics, International Agency for Research on Cancer, Lyon, France.
Lenka ForetovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and Masaryk University, Brno, Czech Republic.
Marc MaynadieRegistre des Hémopathies Malignes de Côte d'Or, University of Burgundy and Dijon University Hospital, Dijon, France.
Anthony StainesSchool of Nursing and Human Sciences, Dublin City University, Dublin, Ireland.ORCID 0000000191611357
Tracy LightfootDepartment of Health Sciences, University of York, York, UK.
Simon CrouchDepartment of Health Sciences, University of York, York, UK.
Alex SmithDepartment of Health Sciences, University of York, York, UK.
Eve RomanDepartment of Health Sciences, University of York, York, UK.
W Ryan DiverEpidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.ORCID 0000000254189000
Kenneth OffitDepartment of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Andrew ZelenetzDepartment of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Robert J KleinDepartment of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Danylo J VillanoDepartment of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Tongzhang ZhengDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA.
Yawei ZhangDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA.
Theodore R HolfordDepartment of Biostatistics, Yale School of Public Health, New Haven, Connecticut, USA.
Anne KrickerSydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia.
Jenny Turner1] Pathology, Australian School of Advanced Medicine, Macquarie University, Sydney, New South Wales, Australia. [2] Department of Histopathology, Douglass Hanly Moir Pathology, Macquarie Park, New South Wales, Australia.
Melissa C SoutheyDepartment of Pathology, University of Melbourne, Parkville, Victoria, Australia.
Jacqueline Clavel1] Environmental Epidemiology of Cancer Group, INSERM, Centre for Research in Epidemiology and Population Health (CESP), Villejuif, France. [2] UMRS 1018, Université Paris Sud, Villejuif, France.
Jarmo VirtamoDepartment of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
Stephanie WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Elio RiboliSchool of Public Health, Imperial College London, London, UK.
Paolo Vineis1] Human Genetics Foundation, Turin, Italy. [2] Medical Research Council (MRC)-Public Health England (PHE) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Rudolph KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Dimitrios Trichopoulos1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece. [3] Hellenic Health Foundation, Athens, Greece.
Roel C H Vermeulen1] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands. [2] Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
Heiner BoeingDepartment of Epidemiology, German Institute for Human Nutrition, Potsdam, Germany.
Anne TjonnelandDanish Cancer Society Research Center, Copenhagen, Denmark.
Emanuele AngelucciHematology Unit, Ospedale Oncologico di Riferimento Regionale A. Businco, Cagliari, Italy.
Simonetta Di LolloDepartment of Surgery and Translational Medicine, Section of Anatomo-Pathology, University of Florence, Florence, Italy.
Marco RaisDepartment of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Italy.
Brenda M BirmannChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Francine Laden1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA.
Edward Giovannucci1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
Peter Kraft1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.
Jinyan HuangDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
Baoshan Ma1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] College of Information Science and Technology, Dalian Maritime University, Dalian, China.
Yuanqing YeDepartment of Epidemiology, MD Anderson Cancer Center, Houston, Texas, USA.
Brian C H ChiuDepartment of Health Studies, University of Chicago, Chicago, Illinois, USA.
Joshua SampsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Liming Liang1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.
Ju-Hyun ParkDongguk University-Seoul, Seoul, South Korea.
Charles C ChungDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Dennis D WeisenburgerDepartment of Pathology, City of Hope National Medical Center, Duarte, California, USA.
Nilanjan ChatterjeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Joseph F FraumeniDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Susan L SlagerDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Xifeng WuDepartment of Epidemiology, MD Anderson Cancer Center, Houston, Texas, USA.
Silvia de Sanjose1] Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d'Oncologia, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. [2] Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
Karin E SmedbyDepartment of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Gilles Salles1] Laboratoire de Biologie Moléculaire de la Cellule, UMR 5239, CNRS, Pierre-Benite, France. [2] Department of Hematology, Hospices Civils de Lyon, Pierre-Benite, France. [3] Department of Hematology, Université Lyon 1, Pierre-Benite, France.
Christine F Skibola1] Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, Alabama, USA. [2] Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, California, USA.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
National Cancer Institute · USMayo Clinic · USMemorial Sloan Kettering Cancer Center · USHarvard University · USUniversity of York · GBBerkeley Public Health Division · USBrigham and Women's Hospital · USMayo Clinic in Florida · USThe University of Texas MD Anderson Cancer Center · USAmerican Cancer Society · USBC Cancer Agency · CACancer Council Victoria · AUCentre international de recherche sur le cancer · FRCentre Léon Bérard · FRFred Hutch Cancer Center · USGerman Cancer Research Center · DEInstitut d'Investigació Biomédica de Bellvitge · ESMassachusetts Department of Public Health · USStatens Serum Institut · DKUniversité Claude Bernard Lyon 1 · FR

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3M
Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI DAVID L RIMM · 1985 to 2026
$85.0M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
Training CoreP42ES004705 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI MORELLO-FROSCH, RACHEL ADELE · 1987 to 2025
$74.6M
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
The Role of Monocytes in non-Hodgkin LymphomaP50CA097274 · NCI · UNIVERSITY OF IOWA · PI WEINER, GEORGE J. · 2002 to 2021
$45.7M
Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
Intramural NIH HHSNCATS NIH HHS UL1 TR000135NCATS NIH HHS UL1 TR000430NCI NIH HHS K07 CA115687NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA033572NCI NIH HHS P50 CA097274NCI NIH HHS R01 CA092153NCI NIH HHS R01 CA098122NCI NIH HHS R01 CA098661NCI NIH HHS R01 CA129539NCI NIH HHS R01 CA149445NCI NIH HHS R01 CA154643NCI NIH HHS R25 CA098566NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107NHGRI NIH HHS U01 HG007033NIEHS NIH HHS P42 ES004705World Health Organization 001
6 · The paper itself

Abstract

Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10(-21)), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10(-10)), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10(-8)) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10(-13) and 3.63 × 10(-11), respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.

Indexed as

Chromosome MappingComputational BiologyGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansLikelihood FunctionsLymphoma, Large B-Cell, DiffusePolymorphism, Single NucleotideQuantitative Trait LociWhite People

Identifiers

PMID25261932
PMCPMC4213349
OpenAlexW2015410907

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.