ArticleJournal of neuroscience methods2015
Regional and tissue-specific differences in brain glutamate concentration measured by in vivo single voxel MRS.
Article in Journal of neuroscience methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Magnetic Resonance Spectroscopy of Traumatic Brain Injury and Subconcussive Hits: A Systematic Review and Meta-Analysis.Journal of neurotrauma · 2022Pooled it
- Characterising the association between posterior parietal metabolite levels and cortical macrostructure in a cohort spanning childhood to adulthood.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Magnetic Resonance Spectroscopy (MRS) in Alzheimer's Disease.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Early metabolic alterations in the normal‑appearing grey and white matter of patients with clinically isolated syndrome suggestive of multiple sclerosis: A proton MR spectroscopic study.Experimental and therapeutic medicine · 2023Article
- The psychosis human connectome project: Design and rationale for studies of visual neurophysiology.NeuroImage · 2023Article
- Brain metabolites measured with magnetic resonance spectroscopy in pediatric concussion and orthopedic injury: An Advancing Concussion Assessment in Pediatrics (A-CAP) study.Human brain mapping · 2023Article
- Met carriers of the BDNF Val66Met polymorphism show reduced Glx/NAA in the pregenual ACC in two independent cohorts.Scientific reports · 2021Article
- Lipid-suppressed and tissue-fraction corrected metabolic distributions in human central brain structures using 2DBrain and behavior · 2020Article
- Localized Prediction of Glutamate from Whole-Brain Functional Connectivity of the Pregenual Anterior Cingulate Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Metabolite-cycled density-weighted concentric rings k-space trajectory (DW-CRT) enables high-resolution 1 H magnetic resonance spectroscopic imaging at 3-Tesla.Scientific reports · 2018Article
- EditedMagnetic resonance in medicine · 2017Review
- Simultaneous quantification of glutamate and glutamine by J-modulated spectroscopy at 3 Tesla.Magnetic resonance in medicine · 2016Article
- Regional Differences in the Concentrations of Metabolites in the Brain of Healthy Children: A Proton Magnetic Resonance Spectroscopy (Polish journal of radiology · 2016Article
- Amygdala-prefrontal interactions in (mal)adaptive learning.Trends in neurosciences · 2015Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThere is growing interest in characterizing spatial distribution of glutamate (Glu) in brain disorders. Comparing the differences in Glu concentration using magnetic resonance spectroscopy (MRS) is hampered by the confounding effects of different anatomical regions and tissue composition. NEW
methodEffect of tissue composition on Glu concentrations was studied by selecting closely adjacent voxels within a designated cortical region. Glu regional differences were assessed using voxels comprising essentially the same tissue composition from different cortical regions.
resultsUsing point-resolved-spectroscopy (PRESS)-based averaged echo time method, Glu concentration in the anterior cingulate cortex (ACC) was found to correlate strongly with tissue gray matter (GM) fraction (r=0.87, p=10(-5)). No significant regional difference in Glu concentration was found between frontal and occipital lobes (p=0.23) when the two measured voxels had essentially the same tissue composition. COMPARISON WITH EXISTING
methodsThe method of the current study is aimed to circumvent the difficulties in differentiating anatomical region from tissue composition, given that both can lead to Glu variations in brain. Glu concentration versus tissue composition was measured in the same anatomical region, while the comparison of regional differences was performed with the two regions that had essentially the same tissue composition.
conclusionsIn brain cortices, Glu level is significantly higher in GM than in WM. Glu level difference between frontal lobe and occipital lobe is insignificant.
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