Evidence map›Paper›PMID 25261531›Full record

ArticleJournal of the American Heart Association2014

Clinical preventability of 30-day readmission after percutaneous coronary intervention.

Jason H Wasfy, Jordan B Strom, Stephen W Waldo, Cashel O'Brien, Neil J Wimmer, Adrian H Zai, Jennifer Luttrell, John A Spertus, Kevin F Kennedy, Sharon-Lise T Normand and 2 more

Registry-linked trialAbstract readComparative StudyMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04702113 (Evaluating Pharmacogenomic Variants for Cardiology Therapeutics), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04702113 nacompletednot on this mapstarted 2020, after this paper: background citation

Evaluating Pharmacogenomic Variants for Cardiology Therapeutics: the Lighthouse Pilot (Association Between Genetic Variant Scores and P2Y12 Inhibitor Effects)

TypeinterventionalSponsorCipherome, Inc.Ran2020 to 2023Enrolled300ConditionsThrombosis, Stent Thrombosis, Bleeding, Myocardial InfarctionArmsCipherome Lighthouse Pilot
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  10. Moving Beyond the Hospital.Circulation · 2018
    Article
  11. The relative effects of patient and hospital factors on postpartum readmissions.Journal of perinatology : official journal of the California Perinatal Association · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jason H WasfyCardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA (J.H.W., S.W.W., C.B., R.W.Y.).
Jordan B StromDepartment of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA (J.B.S., L.M.).
Stephen W WaldoCardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA (J.H.W., S.W.W., C.B., R.W.Y.).
Cashel O'BrienCardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA (J.H.W., S.W.W., C.B., R.W.Y.).
Neil J WimmerCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (N.J.W.).
Adrian H ZaiLaboratory of Computer Science, Massachusetts General Hospital, Harvard Medical School, Boston, MA (A.H.Z., J.L.).
Jennifer LuttrellLaboratory of Computer Science, Massachusetts General Hospital, Harvard Medical School, Boston, MA (A.H.Z., J.L.).
John A SpertusSaint Luke's Mid America Heart Institute/UMKC, Kansas City, MO (J.A.S., K.F.K.).
Kevin F KennedySaint Luke's Mid America Heart Institute/UMKC, Kansas City, MO (J.A.S., K.F.K.).
Sharon-Lise T NormandDepartment of Health Care Policy, Harvard Medical School, Boston, MA (S.L.T.N.) Department of Biostatistics, Harvard School of Public Health, Boston, MA (S.L.T.N.).
Laura MauriDepartment of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA (J.B.S., L.M.) Harvard Clinical Research Institute, Boston, MA (L.M., R.W.Y.).
Robert W YehCardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA (J.H.W., S.W.W., C.B., R.W.Y.) Harvard Clinical Research Institute, Boston, MA (L.M., R.W.Y.).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly readmission after PCI is an important contributor to healthcare expenditures and a target for performance measurement. The extent to which 30-day readmissions after PCI are preventable is unknown yet essential to minimizing their occurrence. METHODS AND

resultsPCI patients readmitted to hospital at which PCI was performed within 30 days of discharge at the Massachusetts General Hospital and Brigham and Women's Hospital were identified, and their medical records were independently reviewed by 2 physicians. Each reviewer used an ordinal scale (0, not; 1, possibly; 2, probably; and 3, definitely preventable) to rate clinical preventability, and a total sum score ≥2 was considered preventable. Characteristics of preventable and unpreventable readmissions were compared, and predictors of clinical preventability were assessed by using multivariate logistic regression. Of 9288 PCIs performed, 9081 (97.8%) patients survived to initial hospital discharge and 1007 (11.1%) were readmitted to the index hospital within 30 days. After excluding repeat readmissions, 893 readmissions were reviewed. Fair agreement between physician reviewers was observed (weighted κ statistic 0.44 [95% CI 0.39 to 0.49]). After aggregation of scores, 380 (42.6%) readmissions were deemed preventable and 513 (57.4%) were deemed not preventable. Common causes of preventable readmissions included staged PCI without new symptoms (14.7%), vascular/bleeding complications of PCI (10.0%), and congestive heart failure (9.7%).

conclusionsNearly half of 30-day readmissions after PCI may have been prevented by changes in clinical decision-making. Focusing on these readmissions may reduce readmission rates.

Indexed as

AgedAged, 80 and overAge FactorsCohort StudiesCoronary AngiographyCoronary DiseaseCost-Benefit AnalysisDatabases, FactualFemaleHealth Care CostsHumansMaleMedicareMiddle AgedObserver VariationPatient DischargeOutcomes ResearchPercutaneous Coronary InterventionPerformance MetricsQuality ImprovementReadmission

Identifiers

PMID25261531
PMCPMC4323776

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.