ArticleCancer immunology, immunotherapy : CII2015
Identification of tumor-binding scFv derived from clonally related B cells in tumor and lymph node of a patient with breast cancer.
Article in Cancer immunology, immunotherapy : CII, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Immune Crosstalk Between Lymph Nodes and Breast Carcinomas, With a Focus on B Cells.Frontiers in molecular biosciences · 2021Review
- Immunoprofiling of Breast Cancer Antigens Using Antibodies Derived from Local Lymph Nodes.Cancers · 2019Article
- Six novel immunoglobulin genes as biomarkers for better prognosis in triple-negative breast cancer by gene co-expression network analysis.Scientific reports · 2019Article
- Identification of tumor-reactive B cells and systemic IgG in breast cancer based on clonal frequency in the sentinel lymph node.Cancer immunology, immunotherapy : CII · 2018Article
- Sentinel lymph node B cells can predict disease-free survival in breast cancer patients.NPJ breast cancer · 2018Article
- Positive and negative functions of B lymphocytes in tumors.Oncotarget · 2016Review
- A novel anti-p21Ras scFv antibody reacting specifically with human tumour cell lines and primary tumour tissues.BMC cancer · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to determine the clonal relationship between B cells within a breast cancer and the B cells in the tumor-draining lymph node (TDLN). We also determined the binding capacity of antibodies derived from these sources to autologous cancer and autologous noncancer breast tissue. Antibody clonality of B cells derived from tumor and lymph node was determined by analyzing heavy and light chain immunoglobulin sequences. The number of shared clonal groups observed between tumor and lymph node antibodies was significant for both heavy (p = 0.004) and light chain (p = 0.012) populations. Panning with phage-displayed single-chain variable fragment libraries derived from the tumor and lymph node B cells resulted in multiple antibodies that bound autologous tumor. Sequence analysis of enriched antibodies recovered after the third round of panning the tumor and TDLN libraries against autologous tumor lysates had a genetic relationship. These results indicate that B cells infiltrating a patient's breast cancer and B cells present in the tumor-draining lymph node are clonally and functionally related.
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Registered trials
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