Trial reportJournal of assisted reproduction and genetics2014
The strategy of group embryo culture based on pronuclear pattern on blastocyst development: a two center analysis.
Trial report in Journal of assisted reproduction and genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Secretomes from Conventional Insemination and Intra-Cytoplasmic Sperm Injection Derived Embryos Differentially Modulate Endometrial Cells In Vitro.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Exosomes as modulators of embryo implantation.Molecular biology reports · 2024Review
- Post-Thaw Day 5 Blastocyst Culture Time Prior to Transfer Does Not Affect Assisted Reproduction Technology (ART) Outcomes in Frozen-Thawed Embryo Transfer Cycles.Journal of clinical medicine · 2022Article
- Oocyte quality in women with thalassaemia major: insights from IVF cycles.European journal of obstetrics & gynecology and reproductive biology: X · 2019Article
- Multifactorial analysis of the stochastic epigenetic variability in cord blood confirmed an impact of common behavioral and environmental factors but not of in vitro conception.Clinical epigenetics · 2018Article
- Secretome of in vitro cultured human embryos contains extracellular vesicles that are uptaken by the maternal side.Scientific reports · 2017Article
- Are extremely high progesterone levels still an issue in IVF?Journal of endocrinological investigation · 2017Observational
- Observational
- Blastocyst culture in the Era of PGS and FreezeAlls: Is a 'C' a failing grade?Human reproduction open · 2017Article
- A Comprehensive Analysis of Body Mass Index Effect on in Vitro Fertilization Outcomes.Nutrients · 2016Article
- Reduced blastocyst formation in reduced culture volume.Journal of assisted reproduction and genetics · 2015Article
- Improved blastocyst formation with reduced culture volume: comparison of three different culture conditions on 1128 sibling human zygotes.Journal of assisted reproduction and genetics · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare two embryo grouping strategies.
methodsRetrospective time-course analysis in two different centres. Two culture protocols were used at the zygote stage: "Random Group" in which zygotes were randomly grouped and "Definite Group" in which zygotes were grouped based on pronuclear pattern. Embryo culture was extended to blastocyst stage. Primary and secondary outcomes were respectively the blastulation rate and the cumulative clinical pregnancy and implantation rates. RESULT(S): A similar blastulation rate [42 and 41% day (5 + 6) blastocysts] was obtained in the two groups. Conversely, after adjusting for baseline and cycle variables, cumulative pregnancy [adjusted Odds Ratio = 2.10 (95%CI: 1.08-4.07)] and implantation [adjusted Odds Ratio = 1.78 (95%CI: 1.06-2.97)] rates were significantly higher in the "Random Group" compared to the "Definite Group". CONCLUSION(S): Two strategies of group culture gave similar results in terms of blastulation rate but the random grouping of zygotes improves pregnancy and implantation rates in IVF-cycles.
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