Evidence map›Paper›PMID 25261342›Full record

ArticleThe journal of pain2014

Mechanisms of exercise-induced hypoalgesia.

Kelli F Koltyn, Angelique G Brellenthin, Dane B Cook, Nalini Sehgal, Cecilia Hillard

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of pain, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed, 8 pooled it
15.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 8 syntheses or guidelines pooled it, 379 citations in OpenAlex.

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  5. Do Endocannabinoids Cause the Runner's High? Evidence and Open Questions.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023
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90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kelli F KoltynUniversity of Wisconsin–Madison, 2000 Observatory Dr, Madison, WI 53706-1121. Koltyn@education.wisc.edu
Angelique G Brellenthin
Dane B Cook
Nalini Sehgal
Cecilia Hillard
University of Wisconsin–Madison · USMedical College of Wisconsin · US

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
INSTITUTIONAL CTSA (UW-MADISON): CLINICAL TRIALSUL1RR025011 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$29.5M
Attenuation of Pain in Men and Women: Mechanisms of Exercise-Induced AnalgesiaR21AR057159 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI KOLTYN, KELLI F · 2010 to 2011
$321k
NCATS NIH HHS UL1 TR000427NCRR NIH HHS 1UL1RR025011NCRR NIH HHS UL1 RR025011NIAMS NIH HHS R21 AR057159NIAMS NIH HHS R21AR057159
6 · The paper itself

Abstract

unlabelledThe purpose of this study was to examine opioid and endocannabinoid mechanisms of exercise-induced hypoalgesia (EIH). Fifty-eight men and women (mean age = 21 years) completed 3 sessions. During the first session, participants were familiarized with the temporal summation of heat pain and pressure pain protocols. In the exercise sessions, following double-blind administration of either an opioid antagonist (50 mg naltrexone) or placebo, participants rated the intensity of heat pulses and indicated their pressure pain thresholds and pressure pain ratings before and after 3 minutes of submaximal isometric exercise. Blood was drawn before and after exercise. Results indicated that circulating concentrations of 2 endocannabinoids, N-arachidonylethanolamine and 2-arachidonoylglycerol, as well as related lipids oleoylethanolamide, palmitoylethanolamide, N-docosahexaenoylethanolamine, and 2-oleoylglycerol, increased significantly (P < .05) following exercise. Pressure pain thresholds increased significantly (P < .05), whereas pressure pain ratings decreased significantly (P < .05) following exercise. Also, temporal summation ratings were significantly lower (P < .05) following exercise. These changes in pain responses did not differ between the placebo and naltrexone conditions (P > .05). A significant association was found between EIH and docosahexaenoylethanolamine. These results suggest involvement of a nonopioid mechanism in EIH following isometric exercise. PERSPECTIVE: Currently, the mechanisms responsible for EIH are unknown. This study provides support for a potential endocannabinoid mechanism of EIH following isometric exercise.

Indexed as

AdolescentAdultAmidesArachidonic AcidsCross-Over StudiesDouble-Blind MethodEndocannabinoidsEthanolaminesExerciseFemaleGlyceridesGlycineHot TemperatureHumansIsometric ContractionMale2-oleoylglycerolAmidesArachidonic AcidsEndocannabinoidsEthanolaminesGlyceridesglyceryl 2-arachidonateGlycineN-arachidonylglycineOleic AcidsoleoylethanolamidepalmidrolPalmitic Acids

Identifiers

PMID25261342
PMCPMC4302052
OpenAlexW2172206302

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.