ArticleThe European respiratory journal2015
Exhaled nitric oxide during infancy as a risk factor for asthma and airway hyperreactivity.
Article in The European respiratory journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- The Relationship of Fractional Exhaled Nitric Oxide in Patients with AECOPD.International journal of chronic obstructive pulmonary disease · 2023Article
- Observational
- An IL-9-pulmonary macrophage axis defines the allergic lung inflammatory environment.Science immunology · 2022Article
- Predictive biomarker modeling of pediatric atopic dermatitis severity based on longitudinal serum collection.Clinical and experimental immunology · 2021Article
- The predictive role of small airway dysfunction and airway inflammation biomarkers for asthma in preschool and school-age children: a study protocol for a prospective cohort study.Translational pediatrics · 2021Article
- 2020 Focused Updates to the Asthma Management Guidelines: A Report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group.The Journal of allergy and clinical immunology · 2020Review
- Fractional Exhaled Nitric Oxide (FENO) in the management of asthma: a position paper of the Italian Respiratory Society (SIP/IRS) and Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC).Multidisciplinary respiratory medicine · 2020Article
- The Role of FeNO in Predicting Asthma.Frontiers in pediatrics · 2019Review
- Observational
- Biomarkers in inflammometry pediatric asthma: utility in daily clinical practice.European clinical respiratory journal · 2017Review
- Is the association between exhaled nitric oxide and asthma symptoms altered by body weight in rural adolescents?Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2016Article
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8 authors at 2 institutions in 1 country.
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Abstract
Childhood asthma is often characterised by elevated exhaled nitric oxide (eNO), decreased lung function, increased airway reactivity and atopy; however, our understanding of when these phenotypic airway characteristics develop remains unclear. This study evaluated whether eNO, lung function, airway reactivity and immune characteristics during infancy are risk factors of asthma at age 5 years. Infants with eczema, enrolled prior to wheezy illness (n=116), had eNO, spirometry, airway reactivity and allergen sensitisation assessed at entry to the study and repeated at age 5 years (n=90). Increasing eNO at entry was associated with an increased risk of asthma (p=0.037) and increasing airway reactivity (p=0.015) at age 5 years. Children with asthma at 5 years of age had a greater increase in eNO between infancy and age 5 years compared with those without asthma (p=0.002). Egg sensitisation at entry was also associated with an increased risk of asthma (p=0.020), increasing eNO (p = 0.002) and lower forced expiratory flows (p=0.029) as a 5 year-old. Our findings suggest that, among infants at high risk for developing asthma, eNO early in life may provide important insights into the subsequent risk of asthma and its airway characteristics.
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