ArticleCell stress & chaperones2015
The polymorphisms in the promoter of HSP90 gene and their association with heat tolerance of bay scallop.
Article in Cell stress & chaperones, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Aquaculture Strategy and Genetic Diversity ofBiology · 2025Article
- Identification of Key Biomarkers of Growth-Related Traits in the Bay Scallop Argopecten irradians irradians via Multi-omics Analysis Strategies.Marine biotechnology (New York, N.Y.) · 2025Article
- Article
- The expression profile of calnexin inFish and shellfish immunology reports · 2021Article
- Article
- Genomic organization and hypoxia inducible factor responsive regulation of teleost hsp90β gene during hypoxia stress.Molecular biology reports · 2021Article
- Genome-Wide Association Study RevealsFrontiers in genetics · 2021Article
- Effects of thermal stress on mortality and HSP90 expression levels in the noble scallops Chlamys nobilis with different total carotenoid content.Cell stress & chaperones · 2020Article
- Genetic polymorphism in Hsp90AA1 gene is associated with the thermotolerance in Chinese Holstein cows.Cell stress & chaperones · 2018Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The heat shock protein 90 (HSP90) is a highly abundant and ubiquitous molecular chaperone which plays essential roles in many cellular processes. In the present study, the messenger RNA (mRNA) expressions of HSP90 after acute heat stress were investigated in two bay scallop populations (Argopecten irradians irradians and Argopecten irradians concentricus). The heat-resistant scallop A. i. concentricus, which is distributed in Zhanjiang, China, exhibited significantly higher induction of HSP90 compared with that of the heat-sensitive scallop A. i. irradians, which is distributed in Qinhuangdao, China. The promoter sequence of HSP90 gene from bay scallop (AiHSP90) was cloned, and the polymorphisms within this region were investigated by sequencing to analyze their association with heat tolerance. A total of six single nucleotide polymorphisms (SNPs), including -1167 T-C, -1023 A-C, -799 C-T, -774 A-G, -686 C-T, and -682 A-C, were identified in the amplified promoter region, and most of them affected the putative transcription factor binding sites except for locus -1167. All the six SNP sites were found to be associated with heat tolerance after Hardy-Weinberg equilibrium (HWE) and association analysis. Moreover, haplotypes CACACC and TCTATC were also found to be associated with heat tolerance based on the result of linkage disequilibrium and association analysis. The results provided insights into the molecular mechanisms underlying the thermal adaptation of different congener endemic bay scallops, which suggested that the increased heat tolerance of A. i. concentricus (compared with A. i. irradians) was associated with the higher expression of AiHSP90. Meanwhile, the six genotypes (-1167 TT, -1023 CC, -799 TT, -774 GG, -686 CC, and -682 AA) and two haplotypes (CACACC and TCTATC) could be used as potential markers for scallop selection breeding with higher heat tolerance.
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