Evidence map›Paper›PMID 25261182›Full record

ArticleThe Journal of arthroplasty2015

The use of warfarin for DVT prophylaxis following hip and knee arthroplasty: how often are patients within their target INR range?

Denis Nam, Anita Sadhu, Jeffrey Hirsh, James A Keeney, Ryan M Nunley, Robert L Barrack

Open access · greenAbstract read
In one paragraph

Article in The Journal of arthroplasty, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 24 citations in OpenAlex.

  1. Management of Venous Thromboembolism After Hip and Knee Arthroplasty.Journal of orthopaedics and sports medicine · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Denis NamWashington University School of Medicine/Barnes-Jewish Hospital, Department of Orthopedic Surgery, St. Louis, Missouri.
Anita SadhuWashington University School of Medicine/Barnes-Jewish Hospital, Department of Orthopedic Surgery, St. Louis, Missouri.
Jeffrey HirshWashington University School of Medicine/Barnes-Jewish Hospital, Department of Orthopedic Surgery, St. Louis, Missouri.
James A KeeneyWashington University School of Medicine/Barnes-Jewish Hospital, Department of Orthopedic Surgery, St. Louis, Missouri.
Ryan M NunleyWashington University School of Medicine/Barnes-Jewish Hospital, Department of Orthopedic Surgery, St. Louis, Missouri.
Robert L BarrackWashington University School of Medicine/Barnes-Jewish Hospital, Department of Orthopedic Surgery, St. Louis, Missouri.
Jewish Hospital · USBarnes-Jewish Hospital · US

Funding

Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Institute of Clinical and Translational SciencesTL1TR000449 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$2.5M
NCATS NIH HHS TL1 TR000449NCATS NIH HHS UL1 TR000448
6 · The paper itself

Abstract

The purpose of this study was to determine the percentage of time that patients are therapeutic when prescribed warfarin for chemical thromboprophylaxis following a hip or knee arthroplasty procedure. One hundred eighty-four patients receiving warfarin for 4weeks postoperatively, dosed using a Web-application accounting for patient demographics, INR levels, and concomitant medication use, were included. Patients with a target INR range between 1.7 and 2.7 were therapeutic for only 54.4% of the time (32.5% subtherapeutic, 13.0% supratherapeutic) while patients with a target INR range between 2.0 and 3.0 were therapeutic for only 45.9% of the time (39.2% subtherapeutic, 14.8% supratherapeutic). Patients receiving warfarin for chemical thromboprophylaxis are within their targeted INR range for only a limited period of time during their postoperative course.

Indexed as

International Normalized RatioAgedAnticoagulantsArthroplasty, Replacement, HipArthroplasty, Replacement, KneeDrug MonitoringFemaleHumansMaleMiddle AgedRetrospective StudiesVenous ThrombosisWarfarinAnticoagulantsWarfarincoumadinthromboprophylaxistotal knee arthroplastyvenous thromboembolismwarfarin

Identifiers

PMID25261182
PMCPMC4324127
OpenAlexW2011715964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.