Evidence map›Paper›PMID 25260967›Full record

Trial reportParkinsonism & related disorders2014

The cognition and emotional well-being indices of the Parkinson's disease questionnaire-39: what do they really measure?

Jacob D Jones, Chris Hass, Paul Mangal, Jacob Lafo, Michael S Okun, Dawn Bowers

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Parkinsonism & related disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Anticholinergic Medication Burden and Cognitive Subtypes in Parkinson's Disease without Dementia.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024
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  11. Predictors of health-related quality of life in Parkinson's disease: the impact of overlap between health-related quality of life and clinical measures.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022
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  18. Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jacob D JonesDepartment of Clinical and Health Psychology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Chris HassDepartment of Applied Physiology and Kinesiology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Paul MangalDepartment of Clinical and Health Psychology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Jacob LafoDepartment of Clinical and Health Psychology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Michael S OkunDepartment of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Dawn BowersDepartment of Clinical and Health Psychology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. Electronic address: dawnbowers@phhp.ufl.edu.

Funding

Research Training in Non-Pharmacological Interventions for Cognition in Aging, MCI, and Alzheimer's DiseaseT32AG020499 · NIA · UNIVERSITY OF FLORIDA · PI MARSISKE, MICHAEL, SMITH, GLENN E. · 2003 to 2024
$3.7M
Interdisciplinary Training in Movement Disorders and NeurorestorationT32NS082168 · NINDS · UNIVERSITY OF FLORIDA · PI Melissa Jo Armstrong, David E Vaillancourt · 2015 to 2026
$2.8M
Emotion Regulation, Executive Function, and Parkinson DiseaseR21NS079767 · NINDS · UNIVERSITY OF FLORIDA · PI BOWERS, DAWN · 2012 to 2013
$392k
NIA NIH HHS T32 AG020499NINDS NIH HHS R21 NS079767NINDS NIH HHS T32 NS082168
6 · The paper itself

Abstract

introductionThe Parkinson's disease questionnaire-39 (PDQ-39) is a common measure of health related quality of life (HRQoL) that is widely used with Parkinson disease (PD) patients. Previous evidence suggests that the PDQ-39 reflects at least 8 dimensions (i.e., Emotion, Cognitions, Mobility, etc). To date, little research has examined the external/convergent validity of the Cognitions and Emotional Well-being domains of the PDQ-39.

methodsA convenience sample of 303 PD patients underwent a comprehensive multi-domain neuropsychological evaluation, including tests of execution function, episodic verbal memory, processing speed, language and working memory, as well as completing measures of depression, apathy, state and trait anxiety and HRQoL (PDQ-39). Hierarchical regressions were conducted in order to examine the relationship between scores on neuropsychological tests and the Cognitions index, as well as mood measures and the Emotional Well-being index of the PDQ-39.

resultsNeuropsychological test performance did not account for a significant amount of variance in the PDQ-39 Cognitions index scores. Instead, it was depression that significantly contributed to the Cognitions index, above and beyond neuropsychological performance. The PDQ-39 Emotional Well-being index was also related to mood measures, primarily depression and trait anxiety.

conclusionsThe PDQ-39 Cognition index may be more related to mood functioning, as opposed to cognitive functioning, and should not be considered a "proxy" for cognitive functioning. Future studies are needed to better explain the construct of this index.

Indexed as

AdultAgedAged, 80 and overAnxietyCognitionDepressionEmotionsFemaleHumansMaleMiddle AgedParkinson DiseaseQuality of LifeSurveys and QuestionnairesCognitionDepressionHealth related quality of lifeParkinson's disease

Identifiers

PMID25260967
PMCPMC4321103

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.