ReviewNeuroscience bulletin2014
Role of cortical spreading depression in the pathophysiology of migraine.
Review in Neuroscience bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Network localization of regional intrinsic neural activity alterations in migraine and their neurochemical correlates.Frontiers in neurology · 2026Pooled it
- Prophylactic Management of Vestibular Migraine: A Systematic Review.Annals of clinical and translational neurology · 2025Pooled it
- Profiling cerebrovascular function in migraine: A systematic review and meta-analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Pooled it
- Pediatric migraine: Neurodevelopmental mechanisms, clinical phenotypes, and modern therapeutics.World journal of clinical pediatrics · 2026Review
- Vascular Changes in the Macula and Peripapillary Regions Using Optical Coherence Tomography Angiography in Migraine with Aura and Migraine Without Aura.Journal of clinical medicine · 2026Article
- Article
- Association between vertebral artery dominance and basilar artery curvature in migraineurs: an anatomical magnetic resonance imaging study.The neuroradiology journal · 2024Article
- The relationship between major depression and migraine: A bidirectional two-sample Mendelian randomization study.Frontiers in neurology · 2023Article
- Visualizing Seizure Propagation in Freely-moving Mice via Miniature Two-photon Microscopy.Neuroscience bulletin · 2022Article
- Review
- Cortical spreading depression: culprits and mechanisms.Experimental brain research · 2022Review
- Complement Component C3 Loss leads to Locomotor Deficits and Altered Cerebellar Internal Granule Cell In Vitro Synaptic Protein Expression in C57BL/6 Mice.Molecular neurobiology · 2021Article
- Review and Hypothesis: A Potential Common Link Between Glial Cells, Calcium Changes, Modulation of Synaptic Transmission, Spreading Depression, Migraine, and Epilepsy-HFrontiers in cellular neuroscience · 2021Article
- Migraine with Brainstem Aura Accompanied by Disorders of Consciousness.Journal of pain research · 2021Review
- The role of the immune system and the biomarker CD3 + CD4 + CD45RA-CD62L- in the pathophysiology of migraine.Scientific reports · 2020Article
- Genetic Screening of Plasticity Regulating Nogo-Type Signaling Genes in Migraine.Brain sciences · 2019Article
- Upregulation of IL-1 Receptor Antagonist in a Mouse Model of Migraine.Brain sciences · 2019Article
- Migraine Modulation and Debut after Percutaneous Atrial Septal Defect Closure: A Review.Frontiers in neurology · 2017Review
- Source localization of intermittent rhythmic delta activity in a patient with acute confusional migraine: cross-spectral analysis using standardized low-resolution brain electromagnetic tomography (sLORETA).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Article
- Cervical non-invasive vagus nerve stimulation (nVNS) for preventive and acute treatment of episodic and chronic migraine and migraine-associated sleep disturbance: a prospective observational cohort study.The journal of headache and pain · 2015Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A migraine is a recurring neurological disorder characterized by unilateral, intense, and pulsatile headaches. In one-third of migraine patients, the attacks are preceded by a visual aura, such as a slowly-propagating scintillating scotoma. Migraine aura is thought to be a result of the neurovascular phenomenon of cortical spreading depression (SD), a self-propagating wave of depolarization that spreads across the cerebral cortex. Several animal experiments have demonstrated that cortical SD causes intracranial neurogenic inflammation around the meningeal blood vessels, such as plasma protein extravasation and pro-inflammatory peptide release. Cortical SD has also been reported to activate both peripheral and central trigeminal nociceptive pathways. Although several issues remain to be resolved, recent evidence suggests that cortical SD could be the initial trigger of intracranial neurogenic inflammation, which then contributes to migraine headaches via subsequent activation of trigeminal afferents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.