ArticleCerebral cortex (New York, N.Y. : 1991)2015
Thalamic Involvement in Fluctuating Cognition in Dementia with Lewy Bodies: Magnetic Resonance Evidences.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Sleep disturbances in Lewy body dementia: A systematic review.International journal of geriatric psychiatry · 2022Pooled it
- Meta-Analysis of Neurochemical Changes Estimated via Magnetic Resonance Spectroscopy in Mild Cognitive Impairment and Alzheimer's Disease.Frontiers in aging neuroscience · 2021Pooled it
- Thalamocortical white matter microstructure and cognition following mild traumatic brain injury: A fixel-based analysis.Brain structure & function · 2026Article
- Neuromodulation of excitation-inhibition balance in dementia with lewy bodies: a translational framework.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Magnetic resonance spectroscopy in hospitalised older people shows age and delirium-specific metabolic changes.Age and ageing · 2026Article
- Dynamic, state-dependent characteristics of cognitive fluctuations in Lewy body dementia: a magnetoencephalography study.Brain communications · 2026Article
- Investigating Dopamine Replacement-Associated Fluctuations in Cognition and Mood in Cognitively Unimpaired Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Dopaminergic deficits along the spectrum of Alzheimer's disease.Molecular psychiatry · 2025Article
- Quantitative electroencephalography in the diagnosis of dementia with Lewy bodies.Clinical neurophysiology practice · 2025Review
- Psychiatric Disorders and Cognitive Fluctuations in Parkinson's Disease: Changing Approaches in the First Decades of the 21st Century.Brain sciences · 2024Review
- The central role of the Thalamus in psychosis, lessons from neurodegenerative diseases and psychedelics.Translational psychiatry · 2023Review
- Functional and structural brain network correlates of visual hallucinations in Lewy body dementia.Brain : a journal of neurology · 2022Article
- EEG Abnormalities During Delirium as a Prodromal Feature of Dementia with Lewy Bodies: A Case Report.Journal of Alzheimer's disease reports · 2022Article
- High γ-Aminobutyric Acid Content Within the Medial Prefrontal Cortex Is a Functional Signature of Somatic Symptoms Disorder in Patients With Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2020Article
- Evaluation of white matter microstructure in patients with Parkinson's disease using microscopic fractional anisotropy.Neuroradiology · 2020Article
- Changes in gray matter volume and functional connectivity in dementia with Lewy bodies compared to Alzheimer's disease and normal aging: implications for fluctuations.Alzheimer's research & therapy · 2020Article
- Proton Magnetic Resonance Spectroscopy in Common Dementias-Current Status and Perspectives.Frontiers in psychiatry · 2020Review
- Early Disruption of Cortical Sleep-Related Oscillations in a Mouse Model of Dementia With Lewy Bodies (DLB) Expressing Human Mutant (A30P) Alpha-Synuclein.Frontiers in neuroscience · 2020Article
- Hallucinations, somatic-functional disorders of PD-DLB as expressions of thalamic dysfunction.Movement disorders : official journal of the Movement Disorder Society · 2019Review
- Transient Daily Episodes of Vision Loss Due to Parkinson's Disease.Neuro-ophthalmology (Aeolus Press) · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dementia with Lewy bodies (DLB) is characterized by fluctuation in cognition and attention. Thalamocortical connectivity and integrity of thalami are central to attentional function. We hypothesize that DLB patients with marked and frequent fluctuating cognition (flCog) have a loss of thalamocortical connectivity, an intrinsic disruption to thalamic structure and imbalances in thalamic neurotransmitter levels. To test this, magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) and proton MR spectroscopy on thalami were performed on 16 DLB, 16 Alzheimer's disease (AD) and 13 healthy subjects. MRI and DTI were combined to subdivide thalami according to their cortical connectivity and to investigate microstructural changes in connectivity-defined thalamic regions. Compared with controls, lower N-acetyl-aspartate/total creatine (NAA/tCr) and higher total choline/total creatine (tCho/tCr) values were observed within thalami of DLB patients. tCho/tCr increase was found within right thalamus of DLB patients as compared with AD. This increase correlated with severity and frequency of flCog. As compared with controls, DLB patients showed bilateral damage within thalamic regions projecting to prefrontal and parieto-occipital cortices, whereas AD patients showed bilateral alteration within thalamic region projecting to temporal cortex. We posit that microstructural thalamic damage and cholinergic imbalance may be central to the etiology of flCog in DLB.
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