ArticleJournal of insect physiology2014
Rhodopsin management during the light-dark cycle of Anopheles gambiae mosquitoes.
Article in Journal of insect physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- The GPROP3 gene controls larval negative phototaxis in Aedes albopictus (Skuse) and shows structural and regulatory conservation across invasive Aedes species.Scientific reports · 2026Article
- Effects of circadian clock disruption on gene expression and biological processes in Aedes aegypti.BMC genomics · 2024Article
- Sleep: An Essential and Understudied Process in the Biology of Blood-Feeding Arthropods.Integrative and comparative biology · 2023Review
- Integrated behavior and transcriptomic analysis provide valuable insights into the response mechanisms ofFrontiers in physiology · 2023Article
- Opsin1 regulates light-evoked avoidance behavior in Aedes albopictus.BMC biology · 2022Article
- Article
- Multimodal synergisms in host stimuli drive landing response in malaria mosquitoes.Scientific reports · 2021Article
- Different as night and day: Behavioural and life history responses to varied photoperiods in Daphnia magna.Molecular ecology · 2019Article
- Olfaction, experience and neural mechanisms underlying mosquito host preference.The Journal of experimental biology · 2018Review
- Insect photoreceptor adaptations to night vision.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Genetic Analysis of Mosquito Detection of Humans.Current opinion in insect science · 2017Review
- The transcriptome of the mosquito Aedes fluviatilis (Diptera: Culicidae), and transcriptional changes associated with its native Wolbachia infection.BMC genomics · 2017Article
- Light-Driven Processes Control Both Rhodopsin Maturation and Recycling in Mosquito Photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The tropical disease vector mosquito Anopheles gambiae possesses 11 rhodopsin genes. Three of these, GPROP1, GPROP3, and GPROP4, encode rhodopsins with >99% sequence identity. We created antisera against these rhodopsins and used immunohistology to show that one or more of these rhodopsins are expressed in the major R1-6 photoreceptor class of the adult A.gambiae eye. Under dark conditions, rhodopsin accumulates within the light-sensitive rhabdomere of the photoreceptor. Light treatment, however, causes extensive movement of rhodopsin to the cytoplasmic compartment. Protein electrophoresis showed that the rhodopsin is present in two different forms. The larger form is an immature species that is deglycosylated during the posttranslational maturation process to generate the smaller, mature form. The immature form is maintained at a constant level regardless of lighting conditions. These results indicate that rhodopsin biosynthesis and movement into the rhabdomere occurs at a constant rate. In contrast, the mature form increases in abundance when animals are placed in dark conditions. Light-triggered internalization and protein degradation counteracts this rhodopsin increase and keeps rhabdomeric rhodopsin levels low in light conditions. The interplay of the constant maturation rate with light-triggered degradation causes rhodopsin to accumulate within the rhabdomere only in dark conditions. Thus, Anopheles photoreceptors possess a mechanism for adjusting light sensitivity through light-dependent control of rhodopsin levels and cellular location.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.